ZIKV er et farlig virus som herjer i verden. Derfor studerer forfatteren i dette tilfellet replikasjonen i den voksne menneskehjernen.
Zikavirus (ZIKV) infiserer hjernevev hos voksne og forårsaker hukommelsessvikt hos mus
A group from the School of Pharmacy led by Claudia Figueiredo (2019) studied how zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Zika virus is an arbovirus belonging to the Flaviviridae family responsible for a recent major outbreak in Latin America.
ZIKV has been found in the brains and CSF of adult patients. NS2B immunoreactivity colocalized with NeuN-immunoreactive cells, but not with GFAP or F4/80, indicating that neurons are targeted by ZikV in the mature human tissue. In adult immunocompetent mice infected by intracerebroventricular infusion of ZIKV, high levels of ZikV RNA are detected in the frontal cortex and hippocampus, and mature neurons are the main cell type infected.
Elevated brain levels of TNF-α, intense microgliosis, upregulated expression of complement system proteins (C1q and C3), and hippocampal synapse damage are verified.
Studien omfattet 9 like store kvadranter.
Kontroller originalartikkel her.
Grafiske sammendrag drevet av Mind the Graph
The first figure represents the case where the human temporal lobe cortical tissue fragments were sectioned into 400 µm slices and maintained in culture for 4 days prior to incubation with ZIKV (107 PFU) or mock medium for 1 h, followed by washout.
Den andre viser at voksne mus fikk en infusjon av 105 PFU ZIKV, UV-inaktivert ZIKV eller mock-medium i lateral ventrikkel i hjernen.
The conclusions seem to back up what was previously known about this subject: “ZIKV targets memory-related brain regions regardless of whether the route of infection is central or peripheral. The virus has been detected in CSF of adult patients with neurological complications,” Figueiredo claimed.
De foreslår at fremtidige studier som tar sikte på å undersøke de langsiktige nevrodegenerative konsekvensene av ZIKV-infeksjon er berettiget. Hvis man finner måter å forebygge signalavvik som fører til hjernedysfunksjon, kan det bane vei for intervensjonsstrategier som kan forsinke eller forebygge utviklingen av alvorlige nevrologiske tilstander.
Avisenes innvirkning og resultater
Vi kan analysere med Altmetric data that this paper’s online attention score is higher enn 95% of all other articles of a similar age in Nature Tidsskrifter.
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