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Vh immunoglobulin element Illustration and Icon
Vh immunoglobulin element
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A schematic icon labeling the variable heavy-chain domain (VH) of an immunoglobulin (Ig). In immunology and molecular biology, this protein domain resides within the heavy chain of an antibody, forming the antigen-binding site with the variable light chain (VL) via complementarity-determining regions (CDRs). Hierarchically, VH lies within the heavy polypeptide of the fragment antigen-binding (Fab) region, present on secreted Ig or on the B-cell receptor (BCR) of lymphocytes, enabling specific antigen recognition.
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