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Transgenic mice fertilized egg Illustration and Icon
Transgenic mice fertilized egg
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A mouse fertilized egg (zygote) is held by a glass holding pipette while a fine injection needle penetrates the zona pellucida to deliver deoxyribonucleic acid (DNA) into a pronucleus, a procedure known as pronuclear injection (PNI). This single cell represents the earliest embryonic stage within the reproductive system of Mus musculus (house mouse). In developmental biology and genetics, the technique produces transgenic embryos by genomic integration of an exogenous transgene. The illustration depicts cell-level micromanipulation performed in vitro under a microscope.
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