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Trail Receptor Illustration and Icon
Trail Receptor
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Schematic of the TRAIL signaling complex showing a trimeric TRAIL (TNFSF10) ligand engaging three death receptor monomers at the plasma membrane. The extracellular domains are rendered as stacked light blue rectangles connected by thin stalks to transmembrane segments, representing DR4/TRAIL-R1 (TNFRSF10A) or DR5/TRAIL-R2 (TNFRSF10B). The arrangement emphasizes trimerization and receptor clustering that initiates DISC assembly via FADD and caspase-8, triggering the extrinsic apoptosis pathway.
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