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Toll like receptor single front Illustration and Icon
Toll like receptor single front
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A simplified schematic depicts a single Toll-like receptor monomer shown with an elongated extracellular ectodomain above a small cytoplasmic signaling domain. In the biological hierarchy, this type I transmembrane membrane protein resides in the plasma or endosomal membrane of immune cells within the innate immune system. In immunology and cell biology, the receptor (TLR, toll-like receptor) functions as a pattern-recognition receptor (PRR) that detects pathogen-associated molecular patterns (PAMPs) and signals via its TIR (Toll/Interleukin-1 receptor) domain to induce cytokine production.
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