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Tnfr tumor necrosis factor receptor Illustration and Icon
Tnfr tumor necrosis factor receptor
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A schematic in immunology and cell biology depicting the tumor necrosis factor receptor (TNFR) as a cell-surface receptor protein embedded in the plasma membrane. Two receptor chains display tandem cysteine-rich domains (CRDs) in the extracellular region, connected to transmembrane and cytoplasmic segments, with clustered globular modules indicating ligand-binding sites for tumor necrosis factor (TNF). As part of the immune system at the cell membrane, TNFR mediates signal transduction that can activate apoptosis, inflammation, or NF-κB (nuclear factor kappa B) pathways.
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