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Tissue histology granuloma zoom Illustration and Icon

Tissue histology granuloma zoom

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Microscopic field illustrating granulomatous inflammation: a granuloma characterized by a central hypocellular, pale zone surrounded by a rim of densely packed, dark-staining nuclei consistent with epithelioid macrophages and lymphocytes. In the biological hierarchy, this is a tissue-level inflammatory lesion within an organ system. In histopathology and immunology, such granulomas form during chronic inflammation to sequester persistent antigens or foreign material, demonstrating peripheral cuffing and reduced cellularity centrally.

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