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Tenofovir disoproxil fumarate Illustration and Icon
Tenofovir disoproxil fumarate
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Skeletal structural formula of tenofovir disoproxil fumarate (TDF), a small-molecule prodrug of tenofovir, a nucleotide reverse transcriptase inhibitor (NRTI). The illustration shows a phosphonate ester with a central phosphorus atom (yellow) linked to oxygens (red), carbons (gray), and nitrogens (blue). In pharmacology and medicinal chemistry, this molecule functions as an antiretroviral and anti‑hepatitis B agent, delivering active tenofovir after ester hydrolysis. It represents a drug molecule within the hierarchy of antiviral therapeutics targeting HIV‑1 and hepatitis B virus polymerases.
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