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Tardive Dyskinesia Mechanism Illustration and Icon
Tardive Dyskinesia Mechanism
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Cartoon of a chemical synapse showing presynaptic vesicles releasing neurotransmitter (red dots) into the synaptic cleft toward postsynaptic receptors. Within the neuroanatomical hierarchy, this depicts a dopaminergic synapse of the basal ganglia within the central nervous system (CNS). In neurophysiology and neuropharmacology, chronic dopamine D2 receptor (D2R) antagonism leads to postsynaptic D2R upregulation and supersensitivity, amplifying dopamine (DA) signaling. This pathological plasticity underlies involuntary movements in tardive dyskinesia (TD). The entity illustrated is a neuronal synapse, a cellular structure mediating neurotransmission.
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