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Pegylated Lipids Illustration and Icon
Pegylated Lipids
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A schematic depicts a PEGylated lipid: an amphiphilic molecule with two hydrophobic acyl chains (tails) and a polar headgroup covalently linked to a polyethylene glycol (PEG) polymer. In the hierarchy of structures, this molecule integrates into a lipid bilayer to help build liposomes or lipid nanoparticles (LNPs). In biochemistry, nanomedicine, and pharmaceutical formulation, PEGylated lipids confer steric stabilization, reduce protein adsorption (opsonization), and prolong circulation, while maintaining membrane integrity and enabling encapsulation and delivery of therapeutic cargo in aqueous environments.
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