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Pag mnase cut run Illustration and Icon
Pag mnase cut run
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A stylized schematic depicts antibody-guided chromatin profiling using a protein A/G–micrococcal nuclease (pAG‑MNase) fusion. The illustration shows an antibody bound to a chromatin target within the nucleus, with the tethered nuclease positioned near nucleosomes (histone octamers wrapped by DNA). In the biological hierarchy, the enzyme–protein complex acts on nucleosomal DNA within chromatin of a eukaryotic cell. In molecular biology and epigenomics, CUT&RUN (Cleavage Under Targets and Release Using Nuclease) maps protein–DNA interactions by targeted DNA cleavage and release.
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