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Pag mnase cut run 2 Illustration and Icon
Pag mnase cut run 2
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A stylized schematic shows an antibody-guided nuclease targeting chromatin to profile protein–DNA interactions. An IgG (immunoglobulin G) binds a chromatin protein on nucleosomes—histone–DNA complexes that form the fundamental unit within eukaryotic chromatin—while a pA/G–MNase (Protein A/G–micrococcal nuclease) associates with the antibody. In molecular biology and epigenetics, this complex enables CUT&RUN (Cleavage Under Targets and Release Using Nuclease) by cleaving adjacent DNA in the nucleus, releasing fragments for sequencing-based mapping of transcription factor or histone modification occupancy.
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