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PI3k Complex I Illustration and Icon
PI3k Complex I
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Schematic of a class I phosphoinositide 3-kinase (PI3K) heterodimer assembled on the inner leaflet of the plasma membrane. The catalytic p110 subunit (green, purple, yellow regions) associates with the regulatory p85 subunit (pink). SH2 domains of p85 dock onto a phosphotyrosine motif from an activated receptor tyrosine kinase, positioning the enzyme along the lipid bilayer (gray/white heads with black tails) to phosphorylate phosphatidylinositol substrates, converting PIP2 to PIP3. The layout highlights ABD, RBD, C2, helical, and kinase domains, as well as nSH2, iSH2, and cSH2 segments involved in activation and membrane engagement.
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