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Orai1 Channel Illustration and Icon
Orai1 Channel
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An abstract cartoon depicting a transmembrane ion channel assembled from cylindrical alpha-helical segments, shown as a small bundle that spans a lipid bilayer. In biological hierarchy, it represents a membrane protein within the plasma membrane of a eukaryotic cell, integral to the calcium signaling pathway. In cell physiology and membrane biochemistry, this pore mediates Ca2+ influx as a Ca2+ release-activated Ca2+ (CRAC) channel during store-operated calcium entry (SOCE), typically gated by STIM1 (stromal interaction molecule 1) to replenish endoplasmic reticulum calcium stores.
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