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Notch 1 4 receptor front 2 Illustration and Icon
Notch 1 4 receptor front 2
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A simplified schematic depicts the NOTCH1–NOTCH4 transmembrane receptor protein as color‑coded blocks indicating the extracellular domain (ECD), a single transmembrane domain (TMD), and the cytoplasmic region that yields the Notch intracellular domain (NICD). Located in the plasma membrane of a eukaryotic cell, this protein fits the hierarchy of a membrane protein within a cell in tissue. In cell biology and developmental biology, the Notch pathway mediates juxtacrine signaling with Delta/Jagged ligands to regulate cell‑fate decisions and transcription.
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