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Nlrp3 inflammasome Illustration and Icon
Nlrp3 inflammasome
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A simplified schematic depicts assembly of the NLRP3 inflammasome, with oligomerized NLRP3 sensors (green), the ASC adaptor (yellow), and caspase-1 subunits (red) forming a cytosolic signaling complex in innate immune cells. In immunology and cell biology, this multiprotein complex activates CASP1 (caspase-1) to process pro–IL-1β (interleukin-1 beta) and pro–IL-18 and to drive pyroptosis, representing a hierarchy of protein components within the cytoplasm of leukocytes in the innate immune system.
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