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Nlrc4 Illustration and Icon
Nlrc4
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A stylized molecular diagram depicts the NLRC4 inflammasome, an innate immune multiprotein complex assembled in the cytosol of immune cells. The receptor protein (NLR family CARD domain‑containing protein 4, NLRC4) oligomerizes to form a platform that recruits the adaptor ASC (apoptosis‑associated speck‑like protein containing a CARD, PYCARD) and pro‑caspase‑1 (CASP1). In immunology and cell biology, this protein complex activates caspase‑1, enabling maturation of the cytokines IL‑1β and IL‑18 and inducing pyroptotic cell death at the cellular level within tissues.
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