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Mutant huntingtin protein Illustration and Icon
Mutant huntingtin protein
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A simplified molecular diagram depicts a polypeptide chain with a discrete red segment embedded within teal residues, indicating a mutated region of HTT (huntingtin). In the cellular hierarchy, this intracellular protein macromolecule operates within cells, where mutation—typically an expanded polyglutamine (polyQ) tract from CAG repeats—drives misfolding, aggregation, and toxic gain-of-function. The image reflects biochemistry and neuropathology, emphasizing disease-associated structural alteration linked to Huntington’s disease.
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