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Metabotropic receptor perspective Illustration and Icon
Metabotropic receptor perspective
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Stylized diagram of a metabotropic receptor (G protein–coupled receptor, GPCR) showing seven transmembrane alpha-helices connected by intracellular and extracellular loops, embedded within the plasma membrane of a eukaryotic cell. In cell biology and biochemistry, this transmembrane protein mediates signal transduction by coupling to heterotrimeric G proteins and activating second-messenger pathways such as cAMP or IP3. Hierarchically, it is a membrane protein at the molecular level within the cell, enabling modulatory responses to extracellular ligands.
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