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liver-fibrogenesis

Liver fibrogenesis Illustration and Icon

Liver fibrogenesis

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A schematic cross-section of liver parenchyma illustrating fibrotic remodeling. A row of epithelial hepatocytes with tight junctions borders the perisinusoidal space, where activated hepatic stellate cells (HSCs) transform into myofibroblast-like cells and secrete extracellular matrix (ECM) fibers, shown as thick collagen bundles. The expanding interstitial stroma disrupts normal sinusoidal architecture. In hepatology and pathology, the image depicts cellular and matrix changes within hepatic tissue that underlie scar formation and progressive fibrosis, a key mechanism of chronic liver disease.

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