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Leukocyte transmigration blood vessel cut Illustration and Icon
Leukocyte transmigration blood vessel cut
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A schematic cross-section of a blood vessel depicts a leukocyte moving from the lumen across the endothelium. A polymorphonuclear leukocyte (PMN, neutrophil) undergoes transendothelial migration (TEM, diapedesis) as the white blood cell (WBC) rolls on endothelial cells (ECs), forms selectin-mediated tethering, establishes integrin-dependent firm adhesion, and squeezes between intercellular junctions. Hierarchically, a motile immune cell (cell level) interacts with vascular endothelium (tissue level) within the circulatory system. In immunology and vascular physiology, this process enables immune surveillance and recruitment to inflamed extravascular tissue.
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