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Leaky gut Illustration and Icon
Leaky gut
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Stylized histologic diagram showing intestinal epithelial cells with apical microvilli separated by widened intercellular spaces, indicating increased paracellular permeability. Within a tissue hierarchy, enterocytes (intestinal epithelial cells, IECs) form a simple columnar epithelium of the mucosa in the gastrointestinal (GI) tract, overlying the lamina propria. The illustration pertains to anatomy, histology, physiology, and pathology, emphasizing barrier dysfunction due to disrupted tight junctions (TJs). Functionally, compromised epithelial barrier permits luminal antigens and microbes to translocate across the gut wall.
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