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Intraepidermal blister skin Illustration and Icon
Intraepidermal blister skin
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Diagram of cutaneous histology showing an intraepidermal blister with a fluid-filled cavity within the epidermis. The epidermal roof (stratum corneum and superficial keratinocytes) separates from the basal and spinous layers that remain attached to the basement membrane zone (BMZ). The dermal–epidermal junction is intact, indicating a split above it. In anatomy, histology, and dermatopathology, this tissue-level lesion represents disrupted keratinocyte adhesion that compromises the barrier function of the skin organ.
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