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Insulin like growth factor molecule igf Illustration and Icon
Insulin like growth factor molecule igf
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A ribbon diagram depicts the tertiary structure of an insulin-like growth factor (IGF) protein, with alpha-helices and flexible loops typical of a small secreted peptide hormone. In biological hierarchy, it is a protein ligand within the endocrine system, acting extracellularly in blood plasma. In biochemistry and molecular biology, IGF binds the insulin-like growth factor 1 receptor (IGF1R) to promote cell growth and survival via phosphoinositide 3-kinase (PI3K)–AKT and mitogen-activated protein kinase (MAPK) signaling.
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