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Immunoglobulin ignar Illustration and Icon
Immunoglobulin ignar
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A schematic of a heavy-chain–only antibody from cartilaginous fishes depicts a Y-shaped IgNAR (immunoglobulin new antigen receptor) dimer with two V-NAR (variable domain of new antigen receptor) antigen-binding tips and tandem CH2–CH5 segments, where CH denotes constant heavy-chain domains. In immunology and structural biology, this protein complex shows variable domains above constant regions within an immunoglobulin molecule of the adaptive immune system, circulating in blood. The molecule enables antigen recognition and neutralization in Chondrichthyes (cartilaginous fishes, e.g., sharks).
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