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Hirschsprung disease Illustration and Icon
Hirschsprung disease
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A schematic of the human large intestine depicts a distal aganglionic segment with proximal dilation, representing functional obstruction of the colon. In anatomical and pathology contexts, the organ (large intestine) is part of the gastrointestinal system, while the intestinal wall contains the enteric nervous system (ENS), including the myenteric (Auerbach) and submucosal (Meissner) plexuses. Loss of enteric ganglion cells in the distal colon/rectum impairs peristalsis, producing megacolon upstream. The site is the lower abdomen of Homo sapiens (human).
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