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Guide rna Illustration and Icon
Guide rna
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A stylized molecular diagram depicts a single‑stranded RNA forming a stem–loop hairpin with a short base‑paired duplex and an adjacent spacer sequence shown as colored nucleotides. In molecular biology and genetics, this noncoding nucleic acid functions as a gRNA (guide RNA) or sgRNA (single‑guide RNA) within the CRISPR–Cas ribonucleoprotein complex, providing sequence-specific recognition of complementary DNA to direct nuclease activity for genome editing. The illustration represents a molecule within a larger protein–RNA complex, emphasizing its role in targeting and cleavage rather than a specific species or tissue site.
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