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Dna damage 2 Illustration and Icon
Dna damage 2
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A schematic diagram of a DNA (deoxyribonucleic acid) duplex shows the sugar–phosphate backbone and paired nucleobases, with lesions highlighted. The molecule, a nucleic acid polymer within genomic material, illustrates base loss (abasic site), base mispairing, and breaks in the phosphodiester backbone, including single-strand breaks (SSBs) and a double-strand break (DSB). In the hierarchy, nucleotides comprise the polymeric DNA molecule within chromosomes. In molecular biology and genetics, such damage compromises replication and transcription and activates DNA repair pathways.
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