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Damaged Endothelium 1 Illustration and Icon
Damaged Endothelium 1
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A schematic cross-section of a blood vessel shows the endothelial lining with focal disruption. Flattened endothelial cells (EC, endothelial cells) border the vascular lumen, while erosions reveal the subendothelial extracellular matrix (ECM) of the tunica intima above collagen-rich connective tissue and underlying vascular smooth muscle cells (VSMC) of the tunica media. In vascular biology, histology, and pathology, this tissue system illustrates how the endothelium acts as a barrier regulating hemostasis, permeability, and vasomotor signaling; injury exposes ECM, promoting platelet adhesion and inflammatory cell recruitment.
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