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Cytokine receptor front Illustration and Icon
Cytokine receptor front
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A schematic front view illustrates a dimeric cytokine receptor complex, showing two parallel transmembrane (TM; transmembrane) subunits with paired extracellular domains embedded in the plasma membrane of a eukaryotic cell. In the biological hierarchy, individual protein subunits assemble into a membrane receptor at the cell surface. In immunology and cell-signaling biochemistry, these receptors bind cytokines and initiate intracellular cascades, commonly activating the JAK–STAT pathway (Janus kinase–signal transducer and activator of transcription) to regulate gene expression and immune responses.
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