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Crispr cas12b Illustration and Icon
Crispr cas12b
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A schematic depicts the CRISPR–Cas12b ribonucleoprotein complex engaging a complementary target within double-stranded DNA (dsDNA), guided by a CRISPR RNA (crRNA) and trans-activating CRISPR RNA (tracrRNA) that together function as a guide RNA (gRNA). In biological hierarchy, the Cas12b endonuclease (protein) acts within the bacterial adaptive immune system and as part of engineered genome editing systems. This topic lies within molecular biology, microbiology, and biochemistry. The enzyme cleaves the protospacer in genomic DNA to generate double-strand breaks, enabling gene disruption and nucleic acid diagnostics.
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