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Complex with dystrophin Illustration and Icon
Complex with dystrophin
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A schematic of the dystrophin-associated protein complex (DGC), a transmembrane protein complex at the sarcolemma of striated muscle fibers. The illustration shows dystrophin as an elongated cytosolic scaffold connecting cortical actin filaments to Ξ²-dystroglycan and the sarcoglycan complex, while extracellular Ξ±-dystroglycan binds matrix ligands. Cytoplasmic partners such as syntrophins and dystrobrevins recruit nNOS (neuronal nitric oxide synthase). In biological hierarchy, it depicts proteins within the plasma membrane of muscle tissue, studied in cell biology and muscle physiology, enabling membrane stabilization during contraction.
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