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Ch1 immunoglobulin element Illustration and Icon
Ch1 immunoglobulin element
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A schematic icon shows a rounded capsule labeled 'CH1', representing the constant heavy chain 1 (CH1) domain of an immunoglobulin (Ig) heavy chain within the antibody fragment antigen-binding (Fab) region. In immunology and structural biology, this protein domain lies between variable heavy (VH) and the hinge, pairs with the light chain constant domain (CL) via disulfide bonding, and stabilizes Fab folding and secretion. Hierarchically, CH1 is a domain within the heavy-chain constant region of the antibody molecule. No species-specific features are indicated.
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