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Cancer cell hypoxia Illustration and Icon
Cancer cell hypoxia
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A simplified schematic of a malignant eukaryotic cell with an irregular contour and a central nucleus represents a hypoxic tumor cell within solid tumor tissue. In oncology and cellular physiology, this cell experiences reduced oxygen tension in the tumor microenvironment, activating hypoxia-responsive pathways such as HIF-1α (hypoxia-inducible factor 1-alpha). Hypoxia drives metabolic reprogramming toward anaerobic glycolysis, promotes angiogenic signaling, and contributes to invasion and therapy resistance. The entity depicted is a cell within neoplastic tissue.
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