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Cancer associated fibroblasts caf cell Illustration and Icon
Cancer associated fibroblasts caf cell
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A simplified schematic of a spindle-shaped cancer-associated fibroblast (CAF) with a central nucleus. In the biological hierarchy, this stromal cell resides within the tumor stroma of the tumor microenvironment (TME). In oncology, pathology, and cell biology, CAFs are fibroblast-lineage cells that synthesize extracellular matrix (ECM) and secrete cytokines and growth factors. Functionally, they remodel ECM, promote angiogenesis, facilitate tumor cell invasion, and modulate immune responses. The entity depicted is a cell type of the tumor stroma in solid tumors.
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