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Calcitriol molecule Illustration and Icon
Calcitriol molecule
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A 2D ball-and-stick chemical structure depicts the secosteroid hormone calcitriol, the active form of vitamin D3. In biological hierarchy, it is a small-molecule ligand within the endocrine system that binds the vitamin D receptor (VDR) to modulate gene transcription. In biochemistry and physiology, 1,25-dihydroxycholecalciferol [1,25(OH)2D3] is synthesized in the kidney and acts on intestine, bone, and kidney to regulate calcium and phosphate homeostasis and promote bone mineralization. The drawing highlights multiple hydroxyl groups on a steroid-derived backbone.
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