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Apaf apoptosis protease Illustration and Icon
Apaf apoptosis protease
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A simplified schematic depicts apoptotic protease activating factor 1 (Apaf-1), a cytosolic adaptor protein in the intrinsic (mitochondria-dependent) apoptosis pathway. In cell biology and biochemistry, this protein assembles into the apoptosome to recruit and activate the initiator cysteine protease caspase-9 (CASP9), thereby triggering downstream caspase cascades. The illustration represents a protein within a eukaryotic cell, emphasizing its functional role in programmed cell death signaling rather than anatomical detail. The site of action is the cytoplasm, downstream of mitochondrial cytochrome c release.
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