{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/zh\/%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%87-%e7%96%be%e7%97%85\/","title":{"rendered":"\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3002\u4e00\u4e2a\u79d1\u5b66\u7684\u4fe1\u606f\u56fe\u8868"},"content":{"rendered":"<p style=\"text-align: justify;\">\u5f53\u6211\u4eec\u770b\u5230\u6211\u4eec\u7684\u7528\u6237\u7684\u60ca\u4eba\u5de5\u4f5c\u65f6\uff0c\u8fd9\u603b\u662f\u4e00\u79cd\u5e86\u795d\u3002\u00a0<a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-graphical-abstracts\/#.W4WUCehKiUk\" target=\"_blank\" rel=\"noopener\">\u6211\u5df2\u7ecf\u5199\u4e86<\/a> \u5173\u4e8eAlessandra Martini\u535a\u58eb\u7684\u7814\u7a76\u3002\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Stefania_Forner3\" target=\"_blank\" rel=\"noopener\">\u65af\u7279\u51e1\u5c3c\u4e9a-\u798f\u5c14\u7eb3<\/a>\u00a0\u548c\u4ed6\u4eec\u7684\u540c\u4e8b\u3002\u4ed6\u4eec\u662f\u52a0\u5dde\u5927\u5b66\u7684\u535a\u58eb\u540e\u7814\u7a76\u4eba\u5458\uff0c\u5e76\u4ecb\u610f\u56fe\u7684\u4f7f\u7528\u8005\u3002  \u51e0\u4e2a\u6708\u524d\uff0c\u6211\u5c55\u793a\u4e86<a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-graphical-abstracts\/#.W4WcaOhKiUl\" target=\"_blank\" rel=\"noopener\"> \u4fe1\u606f\u56fe\u8868<\/a>\u00a0Stefania Forner\u535a\u58eb\u4e3a\u53d1\u8868\u5728\u300aTrends in Neurosciences\u300b\u4e0a\u7684\u9898\u4e3a\u300aAlzheimer's Disease\u7684Synaptic impairment\u300b\u7684\u8bc4\u8bba\u6587\u7ae0\u521b\u4f5c\u3002\u4e00\u4e2a\u5931\u8c03\u7684\u4ea4\u54cd\u4e50\u3002<\/p>\n<p style=\"text-align: justify;\">\u4eca\u5929\uff0c\u6211\u60f3\u8c08\u8c08\u4ed6\u4eec\u7684\u65b0\u8bc4\u8bba\u6587\u7ae0\uff0c\u9898\u4e3a <a href=\"https:\/\/www.researchgate.net\/publication\/323527342_Past_to_Future_What_Animal_Models_Have_Taught_Us_About_Alzheimer's_Disease\" target=\"_blank\" rel=\"noopener\">\u4ece\u8fc7\u53bb\u5230\u672a\u6765\uff1a\u52a8\u7269\u6a21\u578b\u7ed9\u6211\u4eec\u5e26\u6765\u7684\u5173\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u542f\u793a\u3002<\/a><\/p>\n<p style=\"text-align: justify;\">\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u662f\u4e00\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5bfc\u81f4\u8ba4\u77e5\u969c\u788d\u548c\u8bb0\u5fc6\u4e27\u5931\u3002\u4e86\u89e3\u75be\u75c5\u673a\u5236\u5bf9\u4e8e\u63d0\u9ad8\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u548c\u627e\u5230\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u975e\u5e38\u91cd\u8981\u3002\u4eca\u5929\uff0c\u5c3d\u7ba1\u5b66\u672f\u754c\u548c\u5236\u836f\u4e1a\u505a\u51fa\u4e86\u5de8\u5927\u7684\u52aa\u529b\uff0c\u4f46\u4ecd\u7136\u6ca1\u6709\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002AD\u662f\u7f8e\u56fd\u7684\u7b2c\u516d\u5927\u6b7b\u56e0\uff0c\u5f71\u54cd\u5230\u5168\u4e16\u754c3500\u4e07\u4eba\u3002<\/p>\n<h2 style=\"text-align: center;\">\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4fe1\u606f\u56fe\u8868<\/h2>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">\u5927\u591a\u6570AD\u60a3\u8005\u662f\u8001\u5e74\u4eba\uff0c\u4ed6\u4eec\u901a\u5e38\u60a3\u6709\u5404\u79cd\u5408\u5e76\u75c7\u3002\u7cd6\u5c3f\u75c5\u3001\u9aa8\u8d28\u758f\u677e\u75c7\u3001\u80be\u810f\u75be\u75c5\u3001\u80a5\u80d6\u3001\u9ad8\u8840\u538b\u548c\u9ad8\u80c6\u56fa\u9187\/\u8840\u8102\u5f02\u5e38\u3001\u4e2d\u98ce\u548c\u766b\u75eb\u53d1\u4f5c\u662f\u5f71\u54cdAD\u53d1\u75c5\u548c\u53d1\u5c55\u7684\u4e3b\u8981\u5408\u5e76\u75c7\uff0c\u4f7f\u8be5\u75be\u75c5\u7684\u53d1\u75c5\u673a\u5236\u66f4\u52a0\u590d\u6742\u3002<\/p>\n<figure id=\"attachment_8067\" aria-describedby=\"caption-attachment-8067\" style=\"width: 755px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-8067 size-full\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png\" alt=\"\u4fe1\u606f\u56fe\u8868\u795e\u7ecf\u79d1\u5b66\" width=\"755\" height=\"487\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png 755w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience-300x194.png 300w\" sizes=\"(max-width: 755px) 100vw, 755px\" \/><figcaption id=\"caption-attachment-8067\" class=\"wp-caption-text\">\u663e\u793a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u5408\u5e76\u75c7\u7684\u4fe1\u606f\u56fe\u3002\u4ece\u8fc7\u53bb\u5230\u672a\u6765\u3002\u52a8\u7269\u6a21\u578b\u7ed9\u6211\u4eec\u5e26\u6765\u7684\u5173\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u542f\u793a<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<blockquote>\n<p style=\"text-align: justify;\"><em>\u5c3d\u7ba1\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u91cc\u8fdb\u884c\u4e86\u5927\u91cf\u7684\u7814\u7a76\u5de5\u4f5c\uff0c\u4f46\u4ee3\u8868\u8be5\u75be\u75c5\u6700\u5e38\u89c1\u5f62\u5f0f\u7684\u6563\u53d1\u6027AD\uff08sAD\uff09\u7684\u75c5\u56e0\u673a\u5236\u4ecd\u7136\u662f\u672a\u77e5\u7684\u3002\u8fd9\u81f3\u5c11\u90e8\u5206\u662f\u7531\u4e8e\u5927\u591a\u6570sAD\u60a3\u8005\u662f\u8001\u5e74\u4eba\uff0c\u4ed6\u4eec\u901a\u5e38\u60a3\u6709\u5404\u79cd\u5408\u5e76\u75c7\uff08\u5982\u4e2d\u98ce\u3001\u538b\u529b\u3001\u7cd6\u5c3f\u75c5\u3001\u766b\u75eb\u53d1\u4f5c\u3001\u9aa8\u8d28\u758f\u677e\u75c7\u548c\u80be\u810f\u75be\u75c5\uff09\u3002<\/em><\/p>\n<\/blockquote>\n<p>\u4e0b\u4e00\u5f20\u4fe1\u606f\u56fe\u663e\u793a\u4e86tau\u548c\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u5be1\u805a\u4f53\u7684\u5f62\u6210\u548c\u7a81\u89e6\u6bd2\u6027\u7684\u673a\u5236\u3002<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_8068\" aria-describedby=\"caption-attachment-8068\" style=\"width: 544px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-8068 size-full\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2018\/08\/infografico-stefani1a.png\" alt=\"\u65af\u8482\u6cd5\u5c3c\u8d44\u6599\u99861a\" width=\"544\" height=\"386\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infografico-stefani1a.png 544w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infografico-stefani1a-300x213.png 300w\" sizes=\"(max-width: 544px) 100vw, 544px\" \/><figcaption id=\"caption-attachment-8068\" class=\"wp-caption-text\">\u4ece\u8fc7\u53bb\u5230\u672a\u6765\u3002\u52a8\u7269\u6a21\u578b\u7ed9\u6211\u4eec\u5e26\u6765\u7684\u5173\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u542f\u793a<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<blockquote>\n<p style=\"text-align: justify;\"><em>\u5728Tauopathies\u671f\u95f4\uff0c\u6811\u7a81\u68d8\u7684\u6570\u91cf\u51cf\u5c11\u3002Tau\u4e0d\u80fd\u8fdb\u5165\u795e\u7ecf\u5143\u7684\u7ec6\u80de\u6838\uff0c\u5bfc\u81f4DNA\u635f\u4f24\u3002\u7ebf\u7c92\u4f53\u7684\u6570\u91cf\u51cf\u5c11\uff0c\u7a81\u89e6\u524d\u56ca\u6ce1\u7684\u6570\u91cf\u4e5f\u51cf\u5c11\uff0c\u8fd9\u5bfc\u81f4\u7a81\u89e6\u635f\u5931\u3002\u8fd9\u79cd\u635f\u5931\u4e5f\u662f\u7531\u4e8eTau\u8fdb\u5165\u6811\u7a81\u548c\u7a81\u89e6\u540e\u533a\u57df\u3002Tau\u8fd8\u5728\u7ec6\u80de\u5916\u805a\u96c6\uff0c\u4f7f\u5176\u80fd\u591f\u88ab\u5176\u4ed6\u795e\u7ecf\u5143\u6355\u83b7\u3002<\/em><\/p>\n<\/blockquote>\n<p>&nbsp;<\/p>\n<p>\u5979\u8fd8\u521b\u5efa\u4e86\u4e00\u4e2a\u4fe1\u606f\u56fe\uff0c\u663e\u793a\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u6709\u5173\u7684\u708e\u75c7\u673a\u5236\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-8069\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2018\/08\/infografico-stefania.png\" alt=\"\u65af\u8482\u51e1\u5c3c\u8d44\u6599\u9986\" width=\"503\" height=\"677\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infografico-stefania.png 503w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infografico-stefania-223x300.png 223w\" sizes=\"(max-width: 503px) 100vw, 503px\" \/><\/p>\n<p>&nbsp;<\/p>\n<blockquote>\n<p style=\"text-align: justify;\"><em>\u5728\u8fc7\u53bb\u7684\u51e0\u5e74\u91cc\uff0c\u6211\u4eec\u5bf9\u4e86\u89e3\u708e\u75c7\u5982\u4f55\u5f71\u54cd\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u548ctau\u75c5\u7406\u5b66\u7279\u522b\u611f\u5174\u8da3\u3002\u8001\u5e74\u4eba\u5f88\u5bb9\u6613\u53d7\u5230\u75c5\u6bd2\u548c\u7ec6\u83cc\u7684\u611f\u67d3\uff0c\u8fd9\u4e9b\u5fae\u751f\u7269\u5236\u5242\u53ef\u80fd\u4f1a\u52a0\u5267\u5927\u8111\u4e2d\u73b0\u6709\u7684\u708e\u75c7\u72b6\u51b5\uff0c\u52a0\u901f\u8ba4\u77e5\u80fd\u529b\u7684\u4e0b\u964d\u3002<\/em><\/p>\n<\/blockquote>\n<p style=\"text-align: justify;\">\u795d\u8d3aStefania Forner\u535a\u58eb\u7684\u4f1f\u5927\u5de5\u4f5c!<\/p>\n<p style=\"text-align: justify;\">\u5982\u679c\u4f60\u662f\u4e00\u4e2a\u79d1\u5b66\u5bb6\uff0c\u5e76\u60f3\u4e3a\u4f60\u7684\u8bba\u6587\u521b\u5efa\u6f02\u4eae\u7684\u6570\u5b57\uff0c\u4f60\u73b0\u5728\u5c31\u53ef\u4ee5\u6210\u4e3a\u4e00\u4e2a\u5934\u8111\u98ce\u66b4\u56fe\u7684\u7528\u6237\u3002<\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/mindthegraph.com\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-5739\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2016\/03\/untitled-creation63724-2-1024x410.png\" alt=\"\u672a\u547d\u540d\u7684\u521b\u4f5c63724 (2)\" width=\"500\" height=\"200\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/03\/untitled-creation63724-2-1024x410.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/03\/untitled-creation63724-2-300x120.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/03\/untitled-creation63724-2.png 1500w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5f53\u6211\u4eec\u770b\u5230\u6211\u4eec\u7684\u7528\u6237\u7684\u60ca\u4eba\u5de5\u4f5c\u65f6\uff0c\u8fd9\u603b\u662f\u4e00\u79cd\u5e86\u795d\u3002\u6211\u5df2\u7ecf\u5199\u8fc7\u5173\u4e8eAlessandra Martini\u535a\u58eb\u3001Stefania Forner\u535a\u58eb\u548c\u4ed6\u4eec\u540c\u4e8b\u7684\u7814\u7a76\u3002\u4ed6\u4eec\u662f\u52a0\u5dde\u5927\u5b66\u7684\u535a\u58eb\u540e\u7814\u7a76\u4eba\u5458\uff0c\u5e76\u6ce8\u610f\u56fe\u7684\u7528\u6237\u3002  \u51e0\u4e2a\u6708\u524d\uff0c\u6211\u5c55\u793a\u4e86Stefania Forner\u535a\u58eb\u4e3a\u53d1\u8868\u5728Trends [...]\u4e0a\u7684\u8bc4\u8bba\u6587\u7ae0\u5236\u4f5c\u7684\u4fe1\u606f\u56fe\u3002<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and 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