{"id":19837,"date":"2022-09-15T11:59:00","date_gmt":"2022-09-15T14:59:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=19837"},"modified":"2023-03-20T09:54:50","modified_gmt":"2023-03-20T12:54:50","slug":"cutaneous-and-acral-melanoma","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/zh\/%e7%9a%ae%e8%82%a4%e5%92%8c%e8%82%9b%e9%97%a8%e9%bb%91%e8%89%b2%e7%b4%a0%e7%98%a4\/","title":{"rendered":"\u7814\u7a76\u56de\u987e\u3002\u76ae\u80a4\u548c\u9888\u90e8\u9ed1\u8272\u7d20\u7624"},"content":{"rendered":"

\u51e0\u5341\u5e74\u6765\uff0c\u4e00\u4e9b\u4eba\u7fa4\u62a5\u544a\u8bf4\u5168\u4e16\u754c\u7684\u9ed1\u8272\u7d20\u7624\u53d1\u75c5\u7387\u5728\u589e\u52a0\u3002\u76ae\u80a4\u3001\u7c98\u819c\u6216\u8461\u8404\u819c\u4e2d\u7684\u9ed1\u8272\u7d20\u7ec6\u80de\u7684\u80bf\u7624\u88ab\u79f0\u4e3a\u9ed1\u8272\u7d20\u7624\u3002\u5c3d\u7ba1\u5b83\u5728\u6240\u6709\u76ae\u80a4\u6076\u6027\u80bf\u7624\u4e2d\u53605%\uff0c\u4f46\u5728\u6240\u6709\u76ae\u80a4\u764c\u7684\u6b7b\u4ea1\u75c5\u4f8b\u4e2d\uff0c\u5b83\u8981\u627f\u62c5\u8d85\u8fc775%\u7684\u8d23\u4efb\u3002\u00a0<\/p>\n\n\n\n

\u5c3d\u7ba1\u7d2b\u5916\u7ebf\u66b4\u9732\u4e0e\u9ed1\u8272\u7d20\u7624\u53d1\u5c55\u4e4b\u95f4\u7684\u6b63\u76f8\u5173\u5173\u7cfb\u662f\u4f17\u6240\u5468\u77e5\u7684\uff0c\u4f46\u5728\u4eba\u7c7b\u9ed1\u8272\u7d20\u7624\u7ec4\u7ec7\u4e2d\uff0c\u6f5c\u5728\u7684\u8868\u89c2\u9057\u4f20\u673a\u5236\u57fa\u672c\u4e0a\u6ca1\u6709\u88ab\u63a2\u7d22\u3002\u672c\u6587\u5c06\u8ba8\u8bba\u4e0e\u75c5\u7406\u751f\u7269\u5b66\u548c\u7d2b\u5916\u7ebf\u66b4\u9732\u6709\u5173\u7684\u9884\u540e\u764c\u75c7\u9a71\u52a8\u56e0\u7d20\uff0c\u4ee5\u53ca\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u8bdd\u9898\u7684\u89c1\u89e3\u3002 <\/p>\n\n\n\n

\u7814\u7a76\u7684\u76ee\u7684<\/h2>\n\n\n\n

\u5229\u7528\u4e24\u4e2a\u72ec\u7acb\u7684\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u961f\u5217\uff0c\u4ed6\u4eec\u65e8\u5728\u53d1\u73b0\u548c\u9a8c\u8bc1\u4e0e\u7d2b\u5916\u7ebf\u7a81\u53d8\u6709\u5173\u7684\u5168\u57fa\u56e0\u7ec4\u7532\u57fa\u5316\u6539\u53d8\u3002\u4e00\u4e2a\u5173\u952e\u76ee\u6807\u662f\u7814\u7a76DNA\u7532\u57fa\u5316\u7ec4\u4e0e\u8f6c\u5f55\u7ec4\u4ee5\u53ca\u7efc\u5408\u7532\u57fa\u5316\u7ec4-\u8f6c\u5f55\u7ec4\u5728\u533a\u5206\u7d2b\u5916\u7ebf\u7a81\u53d8\u548c\u975e\u7d2b\u5916\u7ebf\u7a81\u53d8\u7684\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\u65b9\u9762\u7684\u8bca\u65ad\u6f5c\u529b\u3002 <\/p>\n\n\n\n

\u4f7f\u7528\u7efc\u5408\u7684OMIC\u65b9\u6cd5\uff0c\u4f18\u5148\u8003\u8651\u7684\u5dee\u5f02\u7532\u57fa\u5316\u57fa\u56e0\u7684\u5c0f\u6838\u82f7\u9178\u53d8\u4f53\uff08SNVs\uff09\u548c\u62f7\u8d1d\u6570\u53d8\u4f53\uff08CNVs\uff09\u88ab\u8bc4\u4f30\u4e3a\u764c\u75c7\u9a71\u52a8\u6f5c\u529b\u3002\u8fd9\u9879\u7814\u7a76\u5f97\u5230\u4e86\u53e6\u4e00\u9879\u7814\u7a76\u7684\u8fdb\u4e00\u6b65\u652f\u6301\uff0c\u8be5\u7814\u7a76\u8003\u5bdf\u4e86DNA\u7532\u57fa\u5316\u7ec4\u662f\u5426\u80fd\u591f\u533a\u5206\u4e0e\u66b4\u9732\u4e8e\u7d2b\u5916\u7ebf\u6709\u5173\u7684\u7a81\u51fa\u7684\u9ed1\u8272\u7d20\u7624\u53d8\u4f53\uff08\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\uff09\u548c\u975e\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\uff08\u5c16\u5934\u9ed1\u8272\u7d20\u7624\uff09\u4e4b\u95f4\u7684\u75c5\u7406\u548c\u7d2b\u5916\u7ebf\u76f8\u5173\u7684\u5dee\u5f02\u3002\u8bba\u6587\u4e2d\u7684\u56fe\u8868\u663e\u793a\u4e86\u8be5\u7814\u7a76\u7684\u76ee\u6807\u548c\u8fc7\u7a0b\u662f\u4ec0\u4e48\u3002\u8be5\u56fe\u793a\u662f\u7528 Mind the Graph<\/a><\/strong>.<\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a><\/figure><\/div>\n\n\n
<\/div>\n\n\n\n

\u8be6\u7ec6\u8003\u8651\u7814\u7a76\u5185\u5bb9<\/h2>\n\n\n\n

\u5728\u4e34\u5e8a\u751f\u7269\u6837\u672c\u4e2d\uff0c\u7d2b\u5916\u7ebf\u8f90\u5c04\uff08UV\uff09\u4e0e\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\u6709\u5173\uff0c\u4f46\u8fd9\u4e9b\u673a\u5236\u80cc\u540e\u7684\u8868\u89c2\u9057\u4f20\u5b66\u673a\u5236\u5c1a\u672a\u786e\u5b9a\u3002\u672c\u7814\u7a76\u7eb3\u5165\u4e86112\u4e2a\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684\u591a\u6c11\u65cf\u961f\u5217\uff0c\u8fdb\u884c\u4e34\u5e8a\u3001\u8868\u89c2\u57fa\u56e0\u7ec4\uff08DNA\u7532\u57fa\u7ec4\uff09\u3001\u57fa\u56e0\u7ec4\u548c\u8f6c\u5f55\u7ec4\u5206\u6790\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u786e\u5b9a\u4e86\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684\u514d\u75ab\u548c\u8c03\u8282\u9014\u5f84\u7684\u53d8\u5316\uff0c\u8fd9\u4e9b\u53d8\u5316\u53ef\u80fd\u662f\u8de8\u8d8a\u591aOMIC\u7684\u764c\u75c7\u9a71\u52a8\u56e0\u7d20\u3002<\/p>\n\n\n\n

TAPBP\uff08Tap binding protein gene\uff09\u9664\u4e86\u662f\u53c2\u4e0e\u5ea6\u6700\u9ad8\u7684\u57fa\u56e0\u5916\uff0c\u8fd8\u5173\u952e\u6027\u5730\u53c2\u4e0e\u4e86\u514d\u75ab\u529f\u80fd\uff0c\u51e0\u4e2a\u88ab\u7d2b\u5916\u7ebf\u6539\u53d8\u7684\u7532\u57fa\u5316\u4f4d\u70b9\u5df2\u7ecf\u88ab\u5b9a\u5411\u6d4b\u5e8f\u9a8c\u8bc1\uff0c\u63d0\u4f9b\u4e86\u4e34\u5e8a\u9002\u7528\u7684\u673a\u4f1a\u3002MHC-I\u901a\u8fc7\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\u7684\u6210\u5458TAPBP\u4e0e\u4e0e\u6297\u539f\u5904\u7406\u6709\u5173\u7684\u8f6c\u8fd0\u5668\u76f8\u4e92\u4f5c\u7528\u3002\u4e00\u4e9b\u764c\u75c7\u663e\u793a\u4e86TAPBP\uff08tapasin\uff09\u86cb\u767d\u7684\u4e0b\u8c03\uff0c\u5728\u7ec6\u80de\u56e0\u5b50\u66b4\u9732\u540e\u6062\u590d\u4e86\u3002\u00a0<\/p>\n\n\n\n

\u8fd9\u8868\u660e\uff0cTAPBP\u8868\u8fbe\u4e0d\u8db3\u53ef\u80fd\u662f\u7531\u5931\u8c03\u800c\u4e0d\u662f\u7ed3\u6784\u53d8\u5316\u5f15\u8d77\u7684\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0cTAPBP\u7684DNA\u7532\u57fa\u5316\u6c34\u5e73\u4e0e\u8f6c\u5f55\u660e\u663e\u6210\u53cd\u6bd4\uff0c\u800c\u540e\u8005\u7684\u6539\u53d8\u662f\u7531\u4e8e\u7d2b\u5916\u7ebf\u7167\u5c04\u800c\u4e0d\u662f\u9ed1\u8272\u7d20\u7624\u7684\u75c5\u7406\u7279\u5f81\u3002\u6ca1\u6709\u53d1\u73b0\u975e\u7d2b\u5916\u7ebf\u7a81\u53d8\u7684\u76ae\u80a4\u6216\u5c16\u9510\u7684\u9ed1\u8272\u7d20\u7624\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u7532\u57fa\u5316\u3002<\/p>\n\n\n\n

\u9664\u4e86\u4ee5TAPBP\u4e3a\u4e2d\u5fc3\u7684\u53d1\u73b0\u5916\uff0c\u4ed6\u4eec\u53d1\u73b0\u7d2b\u5916\u7ebf\u7a81\u53d8\u4e0e\u4e00\u7cfb\u5217\u5f71\u54cd\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\u7532\u57fa\u7ec4\u7684\u8868\u89c2\u9057\u4f20\u5b66\u6539\u53d8\u6709\u5173\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\uff0c\u65e0\u8bba\u662f\u7d2b\u5916\u7ebf\u7a81\u53d8\u8fd8\u662f\u975e\u7d2b\u5916\u7ebf\u7a81\u53d8\uff0c\u53ef\u80fd\u90fd\u9700\u8981\u5355\u72ec\u5206\u7c7b\uff0c\u5373\u4f7f\u5b83\u4eec\u88ab\u8ba4\u4e3a\u5177\u6709\u76f8\u540c\u7684\u75c5\u7406\/\u7ec6\u80de\u8d77\u6e90\u3002\u8fd9\u662f\u56e0\u4e3a\u5b83\u4eec\u7684\u8868\u89c2\u57fa\u56e0\u7ec4\u666f\u89c2\u53ef\u80fd\u540c\u65f6\u5305\u542b\u66b4\u9732\u548c\u7ec6\u80de\u7cfb\u7684\u6807\u8bb0\u3002 <\/p>\n\n\n\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u591a\u79cd\u5f3a\u5927\u7684\u6280\u672f\u88ab\u5e94\u7528\u4e8e\u76ae\u80a4\u548c\u5c16\u9510\u6e7f\u75a3\u6837\u672c\uff0c\u5305\u62ecWGS\u3001WES\u3001RNA\u6d4b\u5e8f\u548cDNA\u5168\u7532\u57fa\u7ec4\u5206\u6790\uff0c\u4ee5\u53ca\u6700\u5148\u8fdb\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5de5\u5177\u3002\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u516c\u5f00\u7684\u6570\u636e\uff0c\u5e76\u4ee5\u65b0\u7684\u6570\u636e\u96c6\u4f5c\u4e3a\u8865\u5145\uff0c\u5176\u4e2d\u5305\u62ec\u66f4\u5927\u7684\u6837\u672c\u91cf\u3001\u66f4\u5e7f\u6cdb\u7684\u57fa\u56e0\u7ec4\u8986\u76d6\u3001\u5168\u9762\u7684\u8868\u578b\u8bc4\u4f30\u3001\u4fdd\u5b58\u826f\u597d\u7684\u51b7\u51bb\u7ec4\u7ec7\u6837\u672c\uff0c\u4ee5\u53ca\u5bf9\u9664\u76ae\u80a4\u548c\u6b27\u6d32\u4eba\u4ee5\u5916\u7684\u79cd\u65cf\u7684\u9ed1\u8272\u7d20\u7624\u8fdb\u884c\u8bc4\u4f30\u3002 <\/p>\n\n\n\n

\u8fd9\u9879\u5de5\u4f5c\u53d6\u5f97\u4e86\u4ee5\u4e0b\u6210\u679c<\/h2>\n\n\n\n

(1) \u53d1\u73b0\u53ef\u7528\u4e8e\u764c\u75c7\u98ce\u9669\u5206\u5c42\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n\n\n\n

(2) \u6539\u8fdb\u9ed1\u8272\u7d20\u7624\u7c7b\u578b\u5185\u90e8\u548c\u4e4b\u95f4\u7684\u5206\u7c7b\u3002 <\/p>\n\n\n\n

(3) \u8bc6\u522b\u53ef\u80fd\u8d1f\u8d23\u9ed1\u8272\u7d20\u7624\u53d1\u751f\u7684\u5206\u5b50\u9a71\u52a8\u56e0\u7d20\uff0c\u5728\u6cbb\u7597\u4e2d\u53ef\u4ee5\u4f5c\u4e3a\u76ee\u6807\u3002 <\/p>\n\n\n\n

(4) \u589e\u52a0\u5173\u4e8e\u9ed1\u8272\u7d20\u7624\u75c5\u7406\u7684\u77e5\u8bc6\uff0c\u4ee5\u51cf\u5c11\u4eba\u53e3\u7684\u5dee\u5f02\u3002<\/p>\n\n\n\n

\u8fd9\u9879\u7814\u7a76\u4e3a\u5728\u5176\u4ed6\u7c7b\u578b\u7684\u9ed1\u8272\u7d20\u7624\u4e2d\u8fdb\u884c\u7c7b\u4f3c\u7684\u57fa\u56e0-\u73af\u5883\u8c03\u67e5\u63d0\u4f9b\u4e86\u4e00\u4e2a\u8def\u7ebf\u56fe\uff0c\u5e76\u6db5\u76d6\u4e86\u5e38\u89c1\u7684\u548c\u4e0d\u592a\u5e38\u89c1\u7684\u9ed1\u8272\u7d20\u7624\u3002<\/p>\n\n\n\n

\u4ee5\u66f4\u6709\u6548\u7684\u65b9\u5f0f\u4f20\u8fbe\u51c6\u786e\u7684\u79d1\u5b66\u4fe1\u606f<\/h2>\n\n\n\n

\u8fd9\u7bc7\u7814\u7a76\u8bba\u6587\u975e\u5e38\u6709\u8da3\uff0c\u4e5f\u5f88\u5bb9\u6613\u7406\u89e3\uff0c\u4e3b\u8981\u662f\u56e0\u4e3a\u5b83\u6709\u6f02\u4eae\u7684\u56fe\u5f62\u8bf4\u660e\u3002\u8fd9\u4e9b\u56fe\u8868\u662f\u7528 Mind the Graph<\/a> \u5de5\u5177\u3002\u56fe\u5f62\u8bf4\u660e\u53ef\u4ee5\u901a\u8fc7\u5404\u79cd\u65b9\u5f0f\u4f7f\u8bfb\u8005\u53d7\u76ca\u3002\u4f60\u53ef\u4ee5\u901a\u8fc7\u5728Mind the Graph\u514d\u8d39\u6ce8\u518c\uff0c\u5c1d\u8bd5\u63d0\u9ad8\u4f60\u7684\u7814\u7a76\u6c34\u5e73\uff0c\u5e76\u5c1d\u8bd5\u4f60\u7684\u7b2c\u4e00\u4e2a\u79d1\u5b66\u6570\u5b57\u3002

\u8bf7\u4e0d\u8981\u5fd8\u8bb0\u67e5\u770b\u6211\u4eec\u7684\u6587\u7ae0\"\u79d1\u5b66\u63d2\u56fe\u3002\u901a\u5f80\u89c6\u89c9\u79d1\u5b66\u4e16\u754c\u7684\u94a5\u5319<\/a>“. <\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/figure><\/div>\n\n\n
<\/div>\n\n\n\n
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\u5728\u51e0\u5206\u949f\u5185\u521b\u5efa\u6709\u6548\u7684\u79d1\u5b66\u6570\u5b57<\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

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property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Paper Review: Cutaneous and Acral Melanoma\" \/>\n<meta property=\"og:description\" content=\"This article will discuss the prognostic cancer driver related to pathobiology and ultraviolet exposure along with the author's insights.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/zh\/\u76ae\u80a4\u548c\u809b\u95e8\u9ed1\u8272\u7d20\u7624\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-15T14:59:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-20T12:54:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/cutaneous-acral-melanoma-paper-blog-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1123\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta 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