{"id":16636,"date":"2022-09-10T18:27:00","date_gmt":"2022-09-10T21:27:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16636"},"modified":"2023-03-17T14:47:45","modified_gmt":"2023-03-17T17:47:45","slug":"success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/zh\/%e6%88%90%e5%8a%9f%e6%a1%88%e4%be%8b-fg%e4%bf%a1%e5%8f%b7%e5%9c%a8%e7%bb%93%e8%82%a0%e7%99%8c%e5%99%a8%e5%ae%98%e8%87%aa%e6%88%91%e6%9b%b4%e6%96%b0%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8\/","title":{"rendered":"\u7ed3\u80a0\u764c\u7ec4\u7ec7\u80da\u80ce\u81ea\u6211\u66f4\u65b0\u4e2d\u7684FGF\u4fe1\u53f7\u7684\u4f5c\u7528 \u8bba\u6587\u56de\u987e"},"content":{"rendered":"

\u5229\u7528Mind the Graph\u7684\u56fe\u89e3\uff0c\u60a3\u8005\u6765\u6e90\u7684CRC\u7ec6\u80de\u4e2d\u901a\u8fc7FGFR\u6291\u5236\u5f62\u6210\u7684\u7981\u7528\u7403\u72b6\u4f53\u548c\u7c7b\u5668\u5b98\u66f4\u5bb9\u6613\u7406\u89e3\u3002 <\/p>\n\n\n\n

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\u7814\u7a76\u4e86\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b502\uff08FGF2\uff09\u5728\u7ed3\u76f4\u80a0\u764c\u5e72\u7ec6\u80de\u7684\u81ea\u6211\u66f4\u65b0\u4e2d\u7684\u4f5c\u7528<\/strong><\/h2>\n\n\n\n

J\u00f6rg Otte\u53ca\u5176\u540c\u4e8b\uff082019\u5e74\uff09\u5728 \"FGF\u4fe1\u53f7\u5728\u7ed3\u80a0\u764c\u5668\u5b98\u4e2d\u7684\u81ea\u6211\u66f4\u65b0 \"\u4e2d\u62a5\u544a\u8bf4\uff0c\u5f53\u5e7c\u7a1a\u7684\u5355\u7ec6\u80de\u88ab\u5d4c\u5165Matrigel\u5e76\u5728CSC-\u4ecb\u8d28\u4e2d\u57f9\u517b\u65f6\uff0c\u5728\u6240\u6709\u5206\u6790\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e86\u66f4\u590d\u6742\u7684\u81ea\u6211\u7ec4\u7ec7\u3002 <\/p>\n\n\n\n

\u53d1\u73b0\u4e0eEMT\u76f4\u63a5\u76f8\u5173\u7684\u57fa\u56e0\u4ee5\u53ca\u95f4\u8d28\u548c\u81ea\u6211\u66f4\u65b0\u7684\u8868\u578b\uff08TGFB3\u3001ID1\u3001ID2\u548cID4\uff09\u5728\u5668\u5b98\u4e2d\u88ab\u8fc7\u5ea6\u8868\u8fbe\u3002 <\/p>\n\n\n\n

\u867d\u7136\u6291\u5236FGFR\u5bfc\u81f4MAPK\u4fe1\u53f7\u589e\u5f3a\uff0c\u4f46\u4ed6\u4eec\u89c2\u5bdf\u5230\u8bf1\u5bfc\u5206\u5316\u3001\u5927\u591a\u6570\u5e72\u7ec6\u80de\u6807\u5fd7\u7269\u7684\u635f\u5931\u548c\u4e0a\u76ae\u8868\u578b\u3002 <\/p>\n\n\n\n

\u764c\u75c7\u5e72\u7ec6\u80de\u662f\u6076\u6027\u7ec6\u80de\u7684\u4e00\u4e2a\u4e9a\u7fa4\uff0c\u80fd\u591f\u81ea\u6211\u66f4\u65b0\u5e76\u4f5c\u4e3a\u5206\u5316\u7684\u80bf\u7624\u7ec6\u80de\u7684\u6301\u7eed\u6765\u6e90\u3002\u5728\u4e00\u4e9bCSC\u57f9\u517b\u65b9\u6848\u4e2d\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b502\u662f\u7ef4\u6301\u5e72\u6027\u7684\u91cd\u8981\u6210\u5206\u3002 <\/p>\n\n\n\n

\u53e6\u4e00\u65b9\u9762\uff0c\u5728CSC\u57f9\u517b\u7684\u5668\u5b98\u4e2d\uff0c\u4ed6\u4eec\u68c0\u6d4b\u5230TGF-\u03b2\u548c\u5206\u5316\u6291\u5236\u5242\u57fa\u56e0\u5bb6\u65cf\u7684\u6240\u6709\u56db\u4e2a\u6210\u5458\u7684\u8bf1\u5bfc\u3002<\/p>\n\n\n\n

9\u540d\u8fde\u7eed\u7684\u672a\u7ecf\u9009\u62e9\u7684CRC\u60a3\u8005\u53c2\u4e0e\u4e86\u7814\u7a76\u3002<\/strong><\/p>\n\n\n\n

\u68c0\u67e5 \u539f\u6587\u5728\u6b64<\/a>.<\/p>\n\n\n\n

\u7531Mind the Graph\u63d0\u4f9b\u7684\u56fe\u5f62\u5316\u6458\u8981<\/strong><\/h2>\n\n\n\n
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\u4f7f\u7528\u65b9\u6cd5 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u4ed6\u4eec\u7684\u4e00\u4e9b\u7ed3\u8bba\u53ef\u80fd\u4f1a\u52a0\u5f3a\u4ee5\u524d\u5bf9\u8fd9\u4e2a\u9886\u57df\u7684\u4e86\u89e3\u3002\"\u591a\u80fd\u6027\u76f8\u5173\u7684\u57fa\u56e0NANOG\u3001LIN28\u548cSALL1\u53ea\u7531hESCs\u8868\u8fbe\u3002\u5728\u6211\u4eec\u7684\u80da\u80ce\u5e72\u7ec6\u80de\u57f9\u517b\u4e2d\u68c0\u6d4b\u5230\u4e86GO\u672f\u8bed \"BMP\u4fe1\u53f7\u901a\u8def\u7684\u8d1f\u8c03\u63a7 \"\u548c \"SMAD\u86cb\u767d\u4fe1\u53f7\u8f6c\u5bfc\"\uff0c\"Otte\u8bf4\u3002<\/p>\n\n\n\n

\u4f5c\u8005\u627f\u8ba4\uff0c\"\u7531\u4e8e\u53d7\u666e\u904d\u8c03\u63a7\u7684\u57fa\u56e0\u6570\u91cf\u8f83\u5c11\uff0c\u5bf9\u8fd9\u4e00\u57fa\u56e0\u96c6\u7684GO-\u672f\u8bed\u5206\u6790\u53ea\u4ea7\u751f\u4e86\u4e00\u4e9b\u91cd\u8981\u7ed3\u679c\u3002\u5728CSC-\u4e2d\u7b49\u6761\u4ef6\u4e0b\uff0c\u8fd9\u4e9bGO-\u672f\u8bed\u5927\u591a\u4e0e\u6d3b\u8dc3\u7684\u8f6c\u5f55\u3001\u7ec6\u80de\u589e\u6b96\u6216\u8461\u8404\u7cd6\u6444\u53d6\u589e\u52a0\u6709\u5173\u3002 <\/p>\n\n\n\n

\u5728FGFR\u6291\u5236\u540e\uff0c\u6211\u4eec\u53d1\u73b0\u7ec6\u80de\u5468\u671f\u8c03\u8282\u5668\u4ee5\u53ca\u8bb8\u591a\u88ab\u6ce8\u91ca\u4e3a \"\u4e0a\u76ae\u7ec6\u80de\u5206\u5316\"\u3001\"\u6d88\u5316 \"\u6216 \"\u80c6\u6c41\u9178\u548c\u80c6\u6c41\u76d0\u8fd0\u8f93 \"\u7684\u57fa\u56e0\u3002\"<\/p>\n\n\n\n

\u8bba\u6587\u7684\u5f71\u54cd\u548c\u8868\u73b0<\/strong><\/h2>\n\n\n\n

\u6211\u4eec\u53ef\u4ee5\u7528\u4ee5\u4e0b\u65b9\u6cd5\u8fdb\u884c\u5206\u6790 Altmetric<\/a> \u6570\u636e\u663e\u793a\uff0c\u8be5\u8bba\u6587\u7684\u5728\u7ebf\u5173\u6ce8\u5ea6\u5f97\u5206\u66f4\u9ad8 \u6bd4 68%<\/strong><\/strong> \u5728\u300a\u79d1\u5b66\u62a5\u544a\u300b\u4e2d\u7684\u6240\u6709\u5176\u4ed6\u7c7b\u4f3c\u5e74\u9f84\u7684\u6587\u7ae0\u4e2d\u3002<\/strong><\/p>\n\n\n\n

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\u6765\u6e90 \u8ba1\u91cf\u5b66(Altmetrics)<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

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\n
\u5c1d\u8bd5Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
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