{"id":12121,"date":"2021-01-11T11:05:53","date_gmt":"2021-01-11T13:05:53","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12121"},"modified":"2023-01-05T14:52:03","modified_gmt":"2023-01-05T17:52:03","slug":"cause-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/zh\/%e8%80%81%e5%b9%b4%e7%97%b4%e5%91%86%e7%97%87%e7%9a%84%e7%97%85%e5%9b%a0-%e7%96%be%e7%97%85\/","title":{"rendered":"\u65b0\u7406\u8bba\u8bd5\u56fe\u89e3\u91ca\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u539f\u56e0"},"content":{"rendered":"<p>\u73b0\u5728\u4e00\u534a\u4ee5\u4e0a\u7684\u75f4\u5446\u75c7\u75c5\u4f8b\u88ab\u5f52\u7c7b\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5--\u4e00\u79cd\u6162\u6027\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u9010\u6e10\u5f71\u54cd\u4eba\u7684\u8ba4\u77e5\u548c\u8bb0\u5fc6\u3002 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<\/p>\n\n\n\n<p>\u8fd9\u79cd\u53d8\u5316\u7684\u7ed3\u679c\u662f\u795e\u7ecf\u5143\u5185\u90e8\u7684\u4e0d\u6eb6\u6027\u86cb\u767d\u8d28\u788e\u7247\uff0c\u5206\u89e3\u6574\u4e2a\u7cfb\u7edf\u5e76\u6740\u6b7b\u795e\u7ecf\u5143\u7ec6\u80de\u3002 <\/p>\n\n\n\n<p>\u8fd9\u4e9b\u4e0d\u6eb6\u6027\u7684tau\u86cb\u767d\u788e\u7247\u76f8\u4e92\u805a\u96c6\u5728\u4e00\u8d77\uff0c\u5f62\u6210\u4e86 <strong>\u795e\u7ecf\u7ea4\u7ef4\u7f20\u7ed3\u3002<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/healthy-neurons.png\"><img decoding=\"async\" loading=\"lazy\" width=\"706\" height=\"619\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/healthy-neurons.png\" alt=\"\" class=\"wp-image-12122\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/healthy-neurons.png 706w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/healthy-neurons-300x263.png 300w\" sizes=\"(max-width: 706px) 100vw, 706px\" \/><\/a><\/figure><\/div>\n\n\n<p>\u01de\u01de\u01de <strong>\u8001\u5e74\u6591\u5757<\/strong> \u662f\u7531 <strong>\u6dc0\u7c89\u6837\u86cb\u767d-\u03b2\u80bd<\/strong>.\u5b58\u5728\u4e8e\u795e\u7ecf\u5143\u819c\u4e0a\u7684\u4e00\u79cd\u86cb\u767d\u8d28\uff08\u524d\u6dc0\u7c89\u6837\u86cb\u767d\uff09\u7ecf\u5386\u4e86\u4e00\u4e2a\u88c2\u89e3\u8fc7\u7a0b\uff0c\u5728\u795e\u7ecf\u5143\u5916\u5f62\u6210\u4e86\u81ea\u7531\u7684\u6dc0\u7c89\u6837\u86cb\u767d-\u03b2\u788e\u7247*\u3002 <\/p>\n\n\n\n<p>\u6309\u7406\u8bf4\uff0c\u8fd9\u4e9b\u788e\u7247\u5e94\u8be5\u7531\u7279\u6b8a\u7684\u7ec6\u80de\u548c\u9176\u901a\u8fc7\u541e\u566c\u4f5c\u7528\u4ece\u795e\u7ecf\u5143\u5916\u90e8\u4ecb\u8d28\u4e2d\u6e05\u7406\u51fa\u6765\uff0c\u4f46\u7531\u4e8e\u9057\u4f20\u6216\u8001\u5316\u56e0\u7d20\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u5e76\u6ca1\u6709\u8db3\u591f\u6709\u6548\u5730\u53d1\u751f\uff0c\u5bfc\u81f4\u4e0d\u6eb6\u6027\u6dc0\u7c89\u6837\u03b2\u86cb\u767d\u7684\u81ea\u7531\u788e\u7247\u5f00\u59cb\u805a\u96c6\u6210\u6591\u5757\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/senile-plaques.png\"><img decoding=\"async\" loading=\"lazy\" width=\"207\" height=\"217\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/senile-plaques.png\" alt=\"\" class=\"wp-image-12123\"\/><\/a><\/figure><\/div>\n\n\n<p>\u6dc0\u7c89\u6837\u6591\u5757\u662f\u7814\u7a76\u548c\u8ba8\u8bba\u6700\u591a\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u539f\u56e0\u3002\u4f46\u79d1\u5b66\u5bb6\u4eec\u4e5f\u80af\u5b9a\u795e\u7ecf\u7ea4\u7ef4\u7f20\u7ed3\u4e0e\u75be\u75c5\u7684\u53d1\u5c55\u76f4\u63a5\u76f8\u5173\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/amyloid-beta.png\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/amyloid-beta-1024x768.png\" alt=\"\" class=\"wp-image-12124\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/amyloid-beta-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/amyloid-beta-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/amyloid-beta-768x576.png 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/amyloid-beta-1536x1152.png 1536w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/amyloid-beta.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<p>\u79d1\u5b66\u5bb6\u4eec\u8fd8\u5728\u5065\u5eb7\u7684\u6b7b\u540e\u5927\u8111\u4e2d\u53d1\u73b0\u4e86\u6dc0\u7c89\u6837\u7684\u7ed3\u5757\u3002\u610f\u5473\u7740\u5728\u5065\u5eb7\u7684\u8001\u5e74\u5927\u8111\u4e2d\uff0c\u6e05\u6d01\u8fc7\u7a0b\u4e5f\u53d8\u5f97\u4e0d\u90a3\u4e48\u6709\u6548\uff0c\u4f46\u4e0d\u50cf\u60a3\u6709\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c5\u7684\u5927\u8111\u90a3\u6837\u591a\u3002<\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c\u5927\u91cf\u7684\u8fd9\u4e9b\u8001\u5e74\u6591\u5757\u548c\u795e\u7ecf\u7ea4\u7ef4\u7f20\u7ed3\u662f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u7279\u5f81\uff1b\u5b83\u4eec\u5bf9\u5927\u8111\u7684\u6bd2\u6027\u6781\u5927\uff0c\u6539\u53d8\u4e86\u7a81\u89e6\u7684\u6548\u7387\u548c\u8d28\u91cf\u3002 <\/p>\n\n\n\n<p>\u53d7\u5f71\u54cd\u7684\u5bf9\u8c61\u8868\u73b0\u51fa\u7684\u75c7\u72b6\u5305\u62ec\u8bb0\u5fc6\u529b\u4e0b\u964d\u3001\u4e0e\u65f6\u95f4\u548c\u5730\u70b9\u6709\u5173\u7684\u6df7\u4e71\u3001\u6291\u90c1\u3001\u7126\u8651\u3001\u8bed\u8a00\u548c\u4ea4\u6d41\u95ee\u9898\u3001\u60c5\u7eea\u4e0d\u7a33\u5b9a\u7b49\u3002<\/p>\n\n\n\n<p><strong>\u5728\u65b0\u63d0\u51fa\u7684\u7406\u8bba\u4e2d<\/strong>\u6dc0\u7c89\u6837\u6591\u5757\u662f\u4fdd\u62a4\u5927\u8111\u514d\u53d7\u5fae\u751f\u7269\u611f\u67d3\u7684\u4e00\u79cd\u673a\u5236\u3002 <\/p>\n\n\n\n<p>\u6dc0\u7c89\u6837\u86cb\u767d-\u03b2\u57fa\u56e0\u5b58\u5728\u4e8e\u810a\u690e\u52a8\u7269\u7fa4\u4f53\u7684\u5f88\u5927\u4e00\u90e8\u5206\uff0c\u5b83\u5728\u4e0d\u540c\u7684\u7269\u79cd\u4e2d\u4fdd\u5b58\u4e86\u597d\u51e0\u4ee3\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u5bf9\u6211\u4eec\u7684\u8eab\u4f53\u5e94\u8be5\u6709\u4e00\u4e2a\u6709\u7528\u548c\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u4f5c\u4e3a\u6709\u5bb3\u7684\u4e1c\u897f--\u5982\u679c\u5b83\u4e0d\u662f\u6709\u6548\u6216\u6709\u76ca\u7684\u4e1c\u897f\uff0c\u8fd9\u4e2a\u57fa\u56e0\u65e9\u5c31\u901a\u8fc7\u8fdb\u5316\u7684\u9014\u5f84\u6d88\u5931\u4e86\u3002<\/p>\n\n\n\n<p>\u79d1\u5b66\u5bb6\u4eec\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u6570\u5343\u4e2a\u6b7b\u540e\u5927\u8111\u8fdb\u884c\u4e86\u7814\u7a76\u3002 <\/p>\n\n\n\n<p>\u5c3d\u7ba1\u7531\u4e8e\u6761\u4ef6\u4e0d\u597d\uff0c\u4ed6\u4eec\u5728\u5206\u6790\u8fd9\u4e9b\u7c7b\u578b\u7684\u5927\u8111\u65f6\u9762\u4e34\u56f0\u96be\uff0c\u4f46\u4ed6\u4eec\u8fd8\u662f\u80fd\u591f\u7814\u7a76\u548c\u6536\u96c6\u4fe1\u606f\uff0c\u4ee5\u4fbf\u540e\u6765\u63d0\u51fa\u4e00\u4e9b\u53ef\u80fd\u7684\u5fae\u751f\u7269\u89e6\u53d1\u56e0\u7d20\u3002 <\/p>\n\n\n\n<p>\u8fd9\u4e9b\u89e6\u53d1\u5668\u662f\u5bf9\u67d0\u4e9b\u7c7b\u578b\u7684\u4eba\u7c7b\u75b1\u75b9\u75c5\u6bd2\u5982\u75b1\u75b9\u75c5\u6bd21\u30016A\u548c7\uff0c\u4ee5\u53ca\u4e09\u79cd\u7ec6\u83cc\u7684\u9632\u5fa1\u673a\u5236\u3002 <em>\u8863\u539f\u4f53\u80ba\u708e<\/em>, <em>\u9c8d\u5c14\u9053\u592b\u6c0f\u83cc<\/em>, <em>\u7259\u9f88\u535f\u5549\u83cc\uff08Porphyromonas gingivalis<\/em>.<\/p>\n\n\n\n<p>\u8be5\u7406\u8bba\u8ba4\u4e3a\uff0c\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u6700\u521d\u5177\u6709\u9632\u5fa1\u529f\u80fd\uff0c\u56f0\u4f4f\u4e86\u5411\u5927\u8111\u79fb\u52a8\u7684\u5fae\u751f\u7269\uff0c\u963b\u6b62\u4e86\u53ef\u80fd\u7684\u611f\u67d3\u6216\u75be\u75c5\u3002 <\/p>\n\n\n\n<p>\u5982\u524d\u6240\u8ff0\uff0c\u7531\u4e8e\u8870\u8001\u7684\u56e0\u7d20\uff0c\u5927\u8111\u5931\u53bb\u4e86\u6709\u6548\u6e05\u7406\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u80fd\u529b\u3002\u56e0\u6b64\uff0c\u5173\u4e8e\u6dc0\u7c89\u6837\u86cb\u767d\u529f\u80fd\u7684\u60f3\u6cd5\u53ef\u80fd\u4e00\u76f4\u662f\u9519\u8bef\u7684\uff1b\u5b83\u53ef\u80fd\u53c2\u4e0e\u4e86\u4e00\u79cd\u5bf9\u6297\u5927\u8111\u5165\u4fb5\u8005\u7684\u6297\u83cc\u4fdd\u62a4\uff0c\u88ab\u5f52\u7c7b\u4e3a\u4e00\u79cd\u6297\u83cc\u80bd\u3002<\/p>\n\n\n\n<p>\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u5f97\u5230\u4e86\u79ef\u6781\u7684\u7ed3\u679c\uff0c\u8bd5\u56fe\u8bc1\u660e\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u53ef\u4ee5\u6740\u6b7b\u5c11\u6570\u5e38\u89c1\u75be\u75c5\u7684\u5fae\u751f\u7269\u3002 <\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u53e6\u4e00\u9879\u4e8e2007\u5e74\u5f00\u59cb\u5e76\u5e94\u4e8e2022\u5e74\u5728\u7ebd\u7ea6\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u7ed3\u675f\u7684\u7814\u7a76\u6b63\u5728\u6d4b\u8bd5\u4e00\u79cd\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u8be5\u836f\u7269\u9002\u7528\u4e8e\u60a3\u6709\u764c\u75c7\u7684\u60a3\u8005\u3002 <s>h<\/s>\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd21\u548c\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff0c\u770b\u770b\u8fd9\u79cd\u836f\u7269\u662f\u5426\u80fd\u51cf\u7f13\u75be\u75c5\u7684\u8fdb\u5c55\u3002 <\/p>\n\n\n\n<p>\u76ee\u524d\uff0c\u6211\u4eec\u552f\u4e00\u80fd\u505a\u7684\u5c31\u662f\u5e0c\u671b\u6700\u597d\uff0c\u5e76\u7b49\u5f85\u7ed3\u679c\u3002<\/p>\n\n\n\n<p>\u8fd9\u4e2a\u65b0\u63d0\u51fa\u7684\u7406\u8bba\u4ecd\u672a\u88ab\u6240\u6709\u79d1\u5b66\u754c\u63a5\u53d7\u3002\u8bb8\u591a\u79d1\u5b66\u5bb6\u8ba4\u4e3a\uff0c\u5373\u4f7f\u8fd9\u4e2a\u65b0\u63d0\u51fa\u7684\u7406\u8bba\u88ab\u8bc1\u5b9e\uff0c\u9057\u4f20\u56e0\u7d20\u548c\u4e0d\u826f\u7a81\u53d8\u4ecd\u5c06\u662f\u8be5\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\u3002 <\/p>\n\n\n\n<p>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4ecd\u7136\u662f\u4e00\u79cd\u5bf9\u5176\u771f\u6b63\u539f\u56e0\u77e5\u4e4b\u751a\u5c11\u7684\u75be\u75c5\uff1b\u6ca1\u6709\u6cbb\u6108\u65b9\u6cd5\uff0c\u4e5f\u6ca1\u6709\u5f88\u591a\u6cbb\u7597\u65b9\u6848\u3002\u5982\u679c\u8fd9\u4e00\u7406\u8bba\u6700\u7ec8\u6210\u4e3a\u4e8b\u5b9e\uff0c\u5b83\u53ef\u80fd\u662f\u671d\u7740\u66f4\u597d\u7684\u6cbb\u7597\u65b9\u5411\u8fc8\u51fa\u7684\u7b2c\u4e00\u6b65\u3002\u8d70\u5411\u79d1\u5b66!<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n<p>ABBOTT, A. \u611f\u67d3\u662f\u5426\u4e3a\u67d0\u4e9b\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u75c5\u4f8b\u63d0\u4f9b\u4e86\u79cd\u5b50\uff1f <strong>\u81ea\u7136\u754c<\/strong>, v. 587, n. 7832, p. 22-25, 4 nov. 2020.<\/p>\n\n\n\n<p>CEC\u00cd, K. \u7b49. \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002 <strong>\u8001\u5e74\u533b\u5b66\u3001\u8001\u5e74\u5b66\u548c\u8001\u9f84\u5316<\/strong>, v. 6, n. 3, p. 273-282, 2012.<\/p>\n\n\n\n<p>MAKIN, S. The amyloid hypothesis on trial. <strong>\u81ea\u7136\u754c<\/strong>, v. 559, n. 7715, p. S4-S7, 25 jul. 2018.<\/p>\n\n\n\n<p>Yoo, K.-Y.; Park, S.-Y.\u841c\u7c7b\u5316\u5408\u7269\u4f5c\u4e3a\u6f5c\u5728\u7684\u6297\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u836f\u7269\u3002 <strong>\u5206\u5b50<\/strong>, v. 17, n. 3, p. 3524-3538, mar.2012.<\/p>\n\n\n\n<p>___<br>\u5982\u679c\u4f60\u9700\u8981\u521b\u5efa\u4e00\u4e2a\u7528\u4e8e\u79d1\u5b66\u76ee\u7684\u7684\u4fe1\u606f\u56fe--\u50cf\u6211\u4e00\u6837--\u5728Mind the Graph\u4e2d\uff0c\u4f60\u53ef\u4ee5\u521b\u5efa\u4f60\u9700\u8981\u548c\u60f3\u8981\u7684\u4efb\u4f55\u7c7b\u578b\u7684\u4fe1\u606f\u56fe\u3002\u8fd9\u4e2a\u5e73\u53f0\u5c31\u662f\u8981\u628a\u79d1\u5b66\u5bb6\u53d8\u6210\u8bbe\u8ba1\u5e08\uff0c\u4ee5\u63d0\u9ad8\u4ed6\u4eec\u7684\u5f71\u54cd\u529b\u5728\u8fd9\u4e2a\u5e73\u53f0\u4e0a\u52a0\u5165\u6211\u4eec\u3002 <a href=\"https:\/\/app.mindthegraph.com\/auth\/register\">\u70b9\u51fb\u8fd9\u91cc<\/a>!<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5982\u4eca\u8d85\u8fc7\u4e00\u534a\u7684\u75f4\u5446\u75c7\u75c5\u4f8b\u88ab\u5f52\u7c7b\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5--\u4e00\u79cd\u6162\u6027\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u9010\u6e10\u5f71\u54cd\u4eba\u7684\u8ba4\u77e5\u548c\u8bb0\u5fc6\u3002\u76f4\u5230\u4eca\u5929\uff0c\u5b83\u8fd8\u88ab\u8ba4\u4e3a\u662f\u7531\u9057\u4f20\u548c\u8001\u5316\u56e0\u7d20\u5f15\u8d77\u7684\uff0c\u8be5\u75be\u75c5\u7684\u6076\u68cd\u548c\u5173\u952e\u7f6a\u9b41\u7978\u9996\u88ab\u5f52\u7ed3\u4e3a[...] \u3002<\/p>","protected":false},"author":4,"featured_media":12125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[213,554,964,136],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New Theory Tries to Explain The Cause of Alzheimer\u2019s<\/title>\n<meta name=\"description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. 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