{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/alzheimers-disease\/","title":{"rendered":"Alzheimer\u2019s disease: A scientific infographic"},"content":{"rendered":"

It’s always a celebration when we see the amazing work of our users.\u00a0I already\u00a0wrote<\/a> about the research of Dr. Alessandra Martini, Dr.\u00a0Stefania Forner<\/a>\u00a0and their colleagues.\u00a0They are Postdoctoral Researchers at University of California and mind the graph users. \u00a0A few months ago, I showed the infographics<\/a>\u00a0Dr. Stefania Forner created for the review article published in Trends in Neurosciences entitled Synaptic impairment in Alzheimer\u2019s Disease: A dysregulated symphony.<\/p>\n

Today, I\u00a0want to talk about their new review article entitled Past to future: what animal models have taught us about Alzheimer\u2019s Disease.<\/a><\/p>\n

Alzheimer’s disease (AD) is a neurodegenerative disorder that causes cognitive deficits and memory loss. Understand the disease mechanism\u00a0is important to improve the life quality of pacients and find an effective treatment. Today, despite immense efforts within academia and the pharmaceutical industry are no effective treatments available. AD is the sixth leading cause of death in the USA and affects 35 million people around the world.<\/p>\n

Alzheimer\u2019s Disease infographics<\/h2>\n

 <\/p>\n

The majority of AD patients are elder subjects that commonly sufferfrom a variety of co-morbidities. Diabetes, osteoporosis, renal disease, obesity, hypertension and hypercholes-terolemia\/dyslipidemia, stroke, and seizure are the main comorbidities affecting the onset and progression of AD, adding intricacy tothe pathogenesis of the disease.<\/p>\n

\"infographic
Infographic showing comorbidities in Alzheimer\u2019s disease (AD). Past to Future: What Animal Models Have Taught Us About Alzheimer\u2019s Disease<\/figcaption><\/figure>\n

 <\/p>\n

\n

Despite intensive research efforts over the past few decades, the mechanisms underlying the etiology of sporadic AD (sAD), which represents the most common form of the disease, remains unknown. This is due, at least in part, to the fact that the majority of sAD patients are elder subjects that commonly suffer from a variety of comorbidities (e.g., stroke, stress,diabetes, seizures, osteoporosis, and renal disease)<\/em><\/p>\n<\/blockquote>\n

The next infographic shows the formation and mechanisms of synaptic toxicity of tau and beta-amyloid oligomers.<\/p>\n

 <\/p>\n

\"infografico
Past to Future: What Animal Models Have Taught Us About Alzheimer\u2019s Disease<\/figcaption><\/figure>\n

 <\/p>\n

\n

During tauopathies, there is a reduction in the number of dendritic spines. Tau does not enter the nucleus of the neuron, resulting in DNA damage. There is a reduction in the number of mitochondria and also in the number of presynaptic vesicles, which leads to synaptic loss. Such loss is also due to the entrance of tau into dendrites and postsynaptic areas. Tau also aggregates extracellularly, enabling it to be captured by other neurons.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

She also created an infographic to show inflammatory mechanisms linked to Alzheimer\u2019s disease (AD)<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

We have been particularly interested, over the past few years, in understanding how inflammation impacts beta-amyloid and tau pathology. Elderly individuals are susceptible to viral and bacterial infections, and these microbial agents could exacerbate the existing inflammatory condition in the brain, accelerating the cognitive decline.<\/em><\/p>\n<\/blockquote>\n

Contragulations Dr. Stefania Forner for your great work!<\/p>\n

If you are a scientist and want to create beautiful figures for your paper, you can become a mind the graph user right now.<\/p>\n

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It’s always a celebration when we see the amazing work of our users.\u00a0I already\u00a0wrote about the research of Dr. Alessandra Martini, Dr.\u00a0Stefania Forner\u00a0and their colleagues.\u00a0They are Postdoctoral Researchers at University of California and mind the graph users. \u00a0A few months ago, I showed the infographics\u00a0Dr. Stefania Forner created for the review article published in Trends […]<\/p>\n","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - 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