{"id":7254,"date":"2017-06-21T17:35:04","date_gmt":"2017-06-21T20:35:04","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=7254"},"modified":"2022-10-18T08:29:23","modified_gmt":"2022-10-18T11:29:23","slug":"alzheimers-graphical-abstracts","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/alzheimers-graphical-abstracts\/","title":{"rendered":"Alzheimer’s graphical abstracts: What’s new in neuroscience in a visual way"},"content":{"rendered":"

We really like to show off our users incredible work – especially if they are publishing papers using Mind the Graph illustrations and tools.<\/span><\/p>\n

So, today we\u2019ll show you the research of a\u00a0premium user at the mind the graph, Stefania Forner<\/a>. \u00a0Her review article\u00a0was recently published in Trends in Neurosciences entitled<\/span> Synaptic impairment in Alzheimer\u2019s Disease: A dysregulated symphony.<\/a> <\/b>\u00a0She made\u00a0two Alzheimer’s graphical abstracts\u00a0to illustrate her work.<\/p>\n

First, let\u2019s begin with a little introduction of Stefania studying field<\/strong>:<\/span><\/p>\n

Alzheimer disease (AD) is a neurodegenerative disorder that causes cognitive deficits and memory loss. \u00a0AD is the sixth leading cause of death in the USA and affects 35 million people<\/strong> around the world. <\/span><\/p>\n

Evidence suggests that there is\u00a0a causal role between the cognitive deficits of AD and synapse loss. Also, synapse dysfunction may are related to two pathological pathway. An extracellular accumulation of beta-amyloid peptide<\/strong> and intracellular accumulation of tau protein<\/strong>.<\/span><\/p>\n

These two process are known to play an important role in AD. However, one of the major fundamental questions that remains is related to the molecular relationship between beta-amyloid and tau, and how these two players interdependently cause impairments in synaptic function in AD.<\/span><\/p>\n

So, to analyse separately tau protein and beta-amyloid peptide effects in synaptic function and AD, Stefania used two graphical abstracts she made at Mind the Graph platform. One to show the formation of beta-amyloid oligomers and their mechanisms of synaptic toxicity and other to show the relation between tau protein and synapses in neurons. \u00a0<\/span><\/p>\n

Alzheimer’s graphical abstracts<\/strong><\/h2>\n

\"Alzheimer<\/a><\/p>\n

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\"alzheimer-disorder-tau\"<\/a><\/p>\n

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“Notably, studies investigating the molecular relationship between A\u00df, tau and synaptic deficits and\/or loss, have shed light on how these pathologies could ultimately lead to cognitive decline in patients. The identification of several potential pre- and postsynaptic pathways may contribute to the underlying clinical symptoms of AD.”<\/p>\n<\/blockquote>\n

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I want graphical abstracts to my research too!<\/b><\/h2>\n

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Graphical abstracts are a way to complement and illustrate main points of your work. If you want to learn about how to make amazing graphical abstracts of your own, here are a couple posts to help you:<\/span><\/p>\n