{"id":9012,"date":"2019-06-03T11:07:17","date_gmt":"2019-06-03T14:07:17","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=9012"},"modified":"2022-10-18T08:23:58","modified_gmt":"2022-10-18T11:23:58","slug":"award-zika-virus-infection","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/odul-zika-virus-enfeksiyonu\/","title":{"rendered":"Zika vir\u00fcs\u00fc: Uzun vadeli sonu\u00e7lara yeni bir \u0131\u015f\u0131k getiren \u00f6d\u00fcll\u00fc \u00e7al\u0131\u015fma"},"content":{"rendered":"

Kullan\u0131c\u0131lar\u0131m\u0131z\u0131n bilimsel \u00e7al\u0131\u015fmalar\u0131n\u0131 g\u00f6stermek her zaman \u015fa\u015f\u0131rt\u0131c\u0131d\u0131r. Bug\u00fcn size Brezilyal\u0131 bilim insan\u0131 Isis de Souza'y\u0131 ve onun zika vir\u00fcs\u00fc ile ilgili \u00e7al\u0131\u015fmalar\u0131n\u0131 sunaca\u011f\u0131m. Isis ve meslekta\u015flar\u0131 farelerde erken ya\u015fta Zika vir\u00fcs\u00fc enfeksiyonunun etkisini inceliyor. Kendisi ayn\u0131 zamanda bir Mind the Graph kullan\u0131c\u0131s\u0131 ve kazanan sunum Mind the Graph'ten g\u00f6rsel kaynaklara sahip. Daha fazla gurur duyamazd\u0131k.<\/p>\n

Zika vir\u00fcs\u00fc nedir?<\/strong><\/h3>\n

Zika vir\u00fcs\u00fc Flaviviridae Ailesine aittir. Bu grup birka\u00e7 patojenik vir\u00fcs i\u00e7ermektedir. En bilineni sar\u0131 humma vir\u00fcs\u00fcd\u00fcr, ailenin tip vir\u00fcs\u00fcd\u00fcr ve ayn\u0131 zamanda flavus kelimesi Latince'de \"sar\u0131\" anlam\u0131na geldi\u011fi i\u00e7in aile ad\u0131n\u0131n sebebidir. Bunun yan\u0131 s\u0131ra, di\u011fer flavivir\u00fcsler Bat\u0131 Nil vir\u00fcs\u00fc, dang vir\u00fcs\u00fc ve kene kaynakl\u0131 ensefalit vir\u00fcs\u00fcd\u00fcr.<\/p>\n

Flaviviridae ailesi ortak boyuta (40-65 nm) ve koruyucu ikozahedral n\u00fckleokapsidlerini \u00f6rten viral zarflara sahiptir. Ayr\u0131ca, genetik materyal RNA'd\u0131r ve elektron mikroskobunda g\u00f6r\u00fcn\u00fcrler.<\/p>\n

A\u015fa\u011f\u0131daki infografik zika vir\u00fcs\u00fcn\u00fcn temel yap\u0131s\u0131n\u0131 g\u00f6stermektedir:<\/p>\n

\"preview_90481\"<\/a><\/p>\n

 Zika \u00f6ncelikle di\u015filer taraf\u0131ndan yay\u0131l\u0131r Stegomya aegypti<\/em> Sivrisinek, yumurtlamak i\u00e7in kana ihtiya\u00e7 duyar. Sivrisinek \u00e7o\u011funlukla g\u00fcnd\u00fcz aktiftir.<\/p>\n

Kazanan ka\u011f\u0131t<\/strong><\/h2>\n

Son zamanlarda bir\u00e7ok ara\u015ft\u0131rmac\u0131, do\u011fu\u015ftan zika vir\u00fcs\u00fcne (ZIKV) maruz kalmayla ili\u015fkili n\u00f6rolojik bozukluklar \u00fczerinde \u00e7al\u0131\u015fmaktad\u0131r.<\/p>\n

Ayr\u0131ca, konjenital mikrosefali ZIKV ile enfekte yenido\u011fanlarda bildirilen en belirgin etkilerden biridir. Bu nedenle, ara\u015ft\u0131rma \u00e7abalar\u0131 ZIKV'nin neden oldu\u011fu konjenital mikrosefalinin mekanizmalar\u0131n\u0131 anlamaya odaklanmaktad\u0131r.<\/p>\n

Bununla birlikte, maruz kalan fet\u00fcslerin yaln\u0131zca 1 ila 13%'si do\u011fumda fiziksel malformasyonlar g\u00f6stermektedir. Bunun yan\u0131 s\u0131ra, perinatal enfeksiyonun uzun vadeli sonu\u00e7lar\u0131 hakk\u0131nda bilgi eksikli\u011fi bulunmaktad\u0131r.<\/p>\n

Bu nedenle, Isis de Souza ve meslekta\u015flar\u0131 fareleri kullanarak davran\u0131\u015fsal ve n\u00f6ropatolojik durumlar\u0131 ve bunlar\u0131n k\u0131sa ve uzun vadeli sonu\u00e7lar\u0131n\u0131 incelediler ve sonu\u00e7lar\u0131 \u015fu ba\u015fl\u0131kl\u0131 bir makalede yay\u0131nlad\u0131lar Farelerde erken ya\u015fta Zika vir\u00fcs\u00fc enfeksiyonunun akut ve kronik n\u00f6rolojik sonu\u00e7lar\u0131.<\/strong><\/p>\n

\u0130nsanlarda, do\u011fumdan aylar veya y\u0131llar sonra ortaya \u00e7\u0131kan zika vir\u00fcs\u00fcne maruz kalma ile ili\u015fkili bir\u00e7ok klinik durum vard\u0131r. Dolay\u0131s\u0131yla, bebekler mikrosefali ile do\u011fmasalar bile, motor bozukluklar, n\u00f6betlerle ili\u015fkili kortikal displazi ve di\u011fer n\u00f6rolojik bozukluklar g\u00f6sterebilirler.<\/p>\n

Yazarlara g\u00f6re, onlar \"yenido\u011fan vah\u015fi tip fareleri sistemik olarak ZIKV ile enfekte etmi\u015f ve enfeksiyonun davran\u0131\u015fsal, n\u00f6ropatolojik ve molek\u00fcler sonu\u00e7lar\u0131n\u0131n uzun vadeli takibini ger\u00e7ekle\u015ftirmi\u015ftir. Farelerde ZIKV enfeksiyonu sonras\u0131 k\u0131sa ve uzun vadeli komplikasyonlar\u0131 rapor ettik ve erken t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc-\u03b1 (TNF-\u03b1) n\u00f6tralizasyonunun bu zararl\u0131 etkileri k\u0131smen \u00f6nledi\u011fini g\u00f6sterdik. Bulgular\u0131m\u0131z, ZIKV'ye do\u011fu\u015ftan maruz kald\u0131ktan sonra \u00e7ocuklarda ve ergenlerde potansiyel n\u00f6ropatolojik komplikasyon y\u00fck\u00fcne \u00f6zel dikkat g\u00f6sterilmesi gerekti\u011fini ortaya koymakta ve n\u00f6roinflamasyonun erken inhibisyonunun ZIKV ile enfekte bebeklerde uzun vadeli n\u00f6rolojik sekelleri \u00f6nlemek i\u00e7in potansiyel bir tedavi olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.\"<\/em><\/p>\n

 GE Healthcare Ya\u015fam Bilimleri taraf\u0131ndan desteklenen \u00f6d\u00fcl<\/strong><\/h2>\n

\"Pr\u00eamio Jovem Talento em Ci\u00eancias da Vida\" veya Ya\u015fam Bilimlerinde Gen\u00e7 Yetenek \u00d6d\u00fcl\u00fc, Brezilya Biyokimya ve Molek\u00fcler Biyoloji Derne\u011fi ve GE Healthcare Ya\u015fam Bilimleri taraf\u0131ndan desteklenmektedir. Bilimsel bir komite, Latin Amerika'n\u0131n d\u00f6rt bir yan\u0131ndan profes\u00f6rleri ve \u00f6\u011frencileri bir araya getiren bir etkinlik olan Y\u0131ll\u0131k Kongre'de \u00e7al\u0131\u015fmalar\u0131n\u0131 sunmalar\u0131 i\u00e7in be\u015f aday se\u00e7ti.<\/p>\n

Komite Isis de Oliveira'y\u0131 se\u00e7ti ve kendisi zika vir\u00fcs\u00fcne maruz kalman\u0131n sonu\u00e7lar\u0131 \u00fczerine yapt\u0131\u011f\u0131 \u00e7al\u0131\u015fmay\u0131 sundu.<\/p>\n

\"bi\u0307li\u0307msel
Isis de Oliveira sonu\u00e7lar\u0131n\u0131 sunarken<\/figcaption><\/figure>\n

\u00dcniversiteye ve e\u011fitimine olanak sa\u011flayan bursa te\u015fekk\u00fcr eden bir yaz\u0131 yazd\u0131. Ayr\u0131ca, gelecek nesillerin de kendisi gibi bilimsel bir kariyer yapma f\u0131rsat\u0131na sahip olmas\u0131n\u0131 umdu\u011funu ifade etti.<\/p>\n

Bu y\u00fczden Isis'i muhte\u015fem \u00e7al\u0131\u015fmas\u0131 i\u00e7in tebrik etmek istiyoruz! Umar\u0131m \u00e7al\u0131\u015fmalar\u0131yla daha fazla insana bilim insan\u0131 olma yolunda ilham verir.<\/p>\n

Bilimde daha iyi ileti\u015fim kurmak i\u00e7in verilerinizi daha g\u00f6rsel hale getirmek istiyorsan\u0131z Mind the Graph'yi deneyebilirsiniz:<\/p>\n

\"grafi\u0307\u011fe<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Kullan\u0131c\u0131lar\u0131m\u0131z\u0131n bilimsel \u00e7al\u0131\u015fmalar\u0131n\u0131 g\u00f6stermek her zaman \u015fa\u015f\u0131rt\u0131c\u0131d\u0131r. Bug\u00fcn size Brezilyal\u0131 bilim insan\u0131 Isis de Souza'y\u0131 ve onun zika vir\u00fcs\u00fc ile ilgili \u00e7al\u0131\u015fmalar\u0131n\u0131 sunaca\u011f\u0131m. Isis ve meslekta\u015flar\u0131 farelerde erken ya\u015fta Zika vir\u00fcs\u00fc enfeksiyonunun etkisini inceliyor. Kendisi ayn\u0131 zamanda bir Mind the Graph kullan\u0131c\u0131s\u0131 ve kazanan sunum [...]<\/p>","protected":false},"author":11,"featured_media":9080,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[40],"tags":[299,282,554,71,775,293,316,315],"yoast_head":"\nZika virus: the award-winning study that sheds light on the future<\/title>\n<meta name=\"description\" content=\"Microcephaly is a known effect related to congenital exposure to zika virus. 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