{"id":8713,"date":"2019-04-18T18:07:31","date_gmt":"2019-04-18T21:07:31","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8713"},"modified":"2022-10-18T08:24:00","modified_gmt":"2022-10-18T11:24:00","slug":"brain-damage-pig-brains-alive-hours-death","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/beyin-hasari-domuz-beyinleri-canli-saat-olum\/","title":{"rendered":"Beyin hasar\u0131: Yeni Nature makalesini anlamak i\u00e7in bir infografik"},"content":{"rendered":"

Yale \u00dcniversitesi'nden bilim insanlar\u0131 domuz beyinlerini \u00f6l\u00fcmden sonra saatlerce v\u00fccut d\u0131\u015f\u0131nda canl\u0131 tuttu. Makale \u00d6l\u00fcmden saatler sonra beyin dola\u015f\u0131m\u0131n\u0131n ve h\u00fccresel fonksiyonlar\u0131n restorasyonu<\/strong> domuz beyni kullan\u0131larak yap\u0131lan ve beyin hasar\u0131 ara\u015ft\u0131rmalar\u0131na \u0131\u015f\u0131k tutabilecek deneyi a\u00e7\u0131kl\u0131yor. Nature dergisi\u00a0yay\u0131nland\u0131 <\/a>17 Nisan'da.<\/p>\n

\"\u0130nsanl\u0131k tarihinin b\u00fcy\u00fck b\u00f6l\u00fcm\u00fcnde \u00f6l\u00fcm \u00e7ok basitti.\"<\/em> diyor Christof Koch. Kendisi Seattle, Washington'daki Allen Beyin Bilimi Enstit\u00fcs\u00fc'n\u00fcn ba\u015fkan\u0131 ve ba\u015f bilim insan\u0131d\u0131r. \"Art\u0131k neyin geri d\u00f6nd\u00fcr\u00fclemez oldu\u011funu sorgulamak zorunday\u0131z.\"\u00a0<\/em><\/p>\n

Bu beyinlerdeki n\u00f6ronlar aras\u0131nda herhangi bir ileti\u015fim yoktu, dolay\u0131s\u0131yla bilin\u00e7 de yoktu. Ancak h\u00fccreler canl\u0131yd\u0131 - ve bu tek ba\u015f\u0131na \u00e7ok b\u00fcy\u00fck bir ke\u015fif.<\/p>\n

\"Daha \u00f6nce elde edilen bulgular, h\u00fccrelerin temelde dakikalar i\u00e7inde bir h\u00fccre \u00f6l\u00fcm\u00fc s\u00fcrecine girdi\u011fini g\u00f6stermi\u015fti.\"<\/em>\u00a0Ara\u015ft\u0131rmay\u0131 y\u00f6neten Yale n\u00f6robilimcisi Nenad Sestan bir bas\u0131n toplant\u0131s\u0131 s\u0131ras\u0131nda \u015funlar\u0131 s\u00f6yledi \"G\u00f6sterdi\u011fimiz \u015fey, h\u00fccre \u00f6l\u00fcm\u00fc s\u00fcrecinin kademeli bir s\u00fcre\u00e7 oldu\u011fu ve bu s\u00fcre\u00e7lerden baz\u0131lar\u0131n\u0131n ertelenebilece\u011fi, korunabilece\u011fi ve hatta tersine \u00e7evrilebilece\u011fidir.\"<\/em><\/p>\n

Beyin hasar\u0131 deneyi<\/strong><\/h3>\n

Nature Magazine'e g\u00f6re, ara\u015ft\u0131rmac\u0131lar alt\u0131 saatlik bir s\u00fcre boyunca beyinlerin ne kadar iyi durumda oldu\u011funu test ettiler. N\u00f6ronlar\u0131n ve di\u011fer beyin h\u00fccrelerinin \u015feker t\u00fcketmek ve karbondioksit \u00fcretmek gibi normal metabolik i\u015flevleri yeniden ba\u015flatt\u0131\u011f\u0131n\u0131 tespit ettiler. Ayr\u0131ca, beyinlerin ba\u011f\u0131\u015f\u0131kl\u0131k sistemleri de \u00e7al\u0131\u015f\u0131yor gibi g\u00f6r\u00fcn\u00fcyordu. Tek tek h\u00fccrelerin ve beyin b\u00f6l\u00fcmlerinin yap\u0131lar\u0131 korunmu\u015ftur. Buna kar\u015f\u0131l\u0131k, besin ve oksijen a\u00e7\u0131s\u0131ndan zengin sol\u00fcsyonu almayan kontrol beyinlerindeki h\u00fccreler \u00e7\u00f6kt\u00fc. Ve bilim insanlar\u0131 tedavi edilen beyinlerden al\u0131nan doku \u00f6rneklerine elektrik uygulad\u0131klar\u0131nda, tek tek n\u00f6ronlar\u0131n hala sinyal ta\u015f\u0131yabildi\u011fini g\u00f6rd\u00fcler.<\/p>\n

Bilim insanlar\u0131, postmortem beyinlerde doku bozulmas\u0131ndan sorumlu baz\u0131 s\u00fcre\u00e7leri hafifletmek i\u00e7in \u00f6zel olarak tasarlanm\u0131\u015f BrainEx adl\u0131 bir sistem olu\u015fturdular. Sistem, BEx perfusat ad\u0131 verilen bir \u00e7\u00f6zeltinin pompalanmas\u0131n\u0131 i\u00e7eriyor. Bu \u00e7\u00f6zelti, kan yerine ge\u00e7en koruyucu, stabilize edici ve kontrast maddelerden olu\u015fan tescilli bir kar\u0131\u015f\u0131md\u0131r. Perf\u00fczat ayr\u0131ca v\u00fccut dokusunun oksidasyonunu ve apoptozu durduran kimyasallar da i\u00e7eriyor. Ayr\u0131ca, amac\u0131 iki y\u00f6nl\u00fc olan bir n\u00f6ral aktivite engelleyici de i\u00e7eriyor. \u00c7\u00f6zeltiyi izole edilmi\u015f beynin ana arterlerine normal v\u00fccut s\u0131cakl\u0131\u011f\u0131nda pompalad\u0131lar.<\/p>\n

 <\/p>\n

\"domuzlar\"<\/a>
Makaledeki \u015fekil b\u00fct\u00fcn bir beynin BEx cihaz\u0131na nas\u0131l ba\u011fland\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Domuz beyninin perf\u00fczyon sistemine ba\u011flant\u0131s\u0131 arteriyel hatlar arac\u0131l\u0131\u011f\u0131yla yap\u0131lm\u0131\u015ft\u0131r.\u00a0<\/strong><\/figcaption><\/figure>\n

 <\/p>\n

Ara\u015ft\u0131rmac\u0131lar, ABD Tar\u0131m Bakanl\u0131\u011f\u0131'na ba\u011fl\u0131 bir mezbahadan al\u0131nan yakla\u015f\u0131k 300 domuz kafas\u0131n\u0131 kulland\u0131. Teknolojiyi optimize ettikten sonra ekip 32 domuz beynini BrainEx sistemine ba\u011flad\u0131. Ba\u011flant\u0131y\u0131 domuzlar \u00f6ld\u00fcr\u00fcld\u00fckten 4 saat sonra ve beyinleri kafataslar\u0131ndan \u00e7\u0131kard\u0131ktan sonra yapt\u0131lar. Pompalar, \u0131s\u0131t\u0131c\u0131lar ve filtrelerden olu\u015fan bu bilgisayarl\u0131 a\u011f, ak\u0131\u015f\u0131, s\u0131cakl\u0131\u011f\u0131 ve tescilli perf\u00fczat sol\u00fcsyonunu alt\u0131 saat boyunca kontrol etti.<\/p>\n

Deneyi anlamak i\u00e7in bir infografik<\/strong><\/h2>\n

 <\/p>\n

\"preview_77833<\/a><\/p>\n

 <\/p>\n

\u0130nfografi\u011fi Mind the Graph kullanarak olu\u015fturdum. Ara\u015ft\u0131rman\u0131zla daha fazla insana ula\u015fmak i\u00e7in \u00e7ekici bilimsel ill\u00fcstrasyonlar kullanmak istiyorsan\u0131z siz de Mind the Graph'i kullanabilirsiniz!<\/p>\n

\"preview_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Yale \u00dcniversitesi'nden bilim insanlar\u0131 domuz beyinlerini \u00f6l\u00fcmden sonra saatlerce v\u00fccut d\u0131\u015f\u0131nda canl\u0131 tuttu. \u00d6l\u00fcmden saatler sonra beyin dola\u015f\u0131m\u0131 ve h\u00fccresel fonksiyonlar\u0131n restorasyonunu konu alan makalede, domuz beyni kullan\u0131larak yap\u0131lan ve beyin hasar\u0131 ara\u015ft\u0131rmalar\u0131na \u0131\u015f\u0131k tutabilecek deney anlat\u0131l\u0131yor. Nature dergisi makaleyi 17 Nisan'da yay\u0131nlad\u0131. \"\u0130nsanl\u0131k tarihinin b\u00fcy\u00fck b\u00f6l\u00fcm\u00fcnde \u00f6l\u00fcm \u00e7ok basitti,\" [...]<\/p>","protected":false},"author":11,"featured_media":8721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[54,288,287,286,282,554,71,964,775,70],"yoast_head":"\nBrain damage: an infographic to understand the new Nature paper - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. 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