{"id":8527,"date":"2019-03-20T18:17:14","date_gmt":"2019-03-20T21:17:14","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8527"},"modified":"2022-10-19T10:38:06","modified_gmt":"2022-10-19T13:38:06","slug":"nature-neuroscience","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/doga-sinirbilim\/","title":{"rendered":"Nature neuroscience: \u015fizofreni ve mikroglia aras\u0131ndaki ba\u011flant\u0131"},"content":{"rendered":"<p>\u015eizofreni, bir ki\u015finin nas\u0131l d\u00fc\u015f\u00fcnd\u00fc\u011f\u00fcn\u00fc, hissetti\u011fini ve davrand\u0131\u011f\u0131n\u0131 etkileyen kronik ve ciddi bir zihinsel bozukluktur. \u015eizofreni hastalar\u0131 ger\u00e7eklikle ba\u011flar\u0131n\u0131 kaybetmi\u015f gibi g\u00f6r\u00fcnebilirler. \u015eizofreni geli\u015fimini anlamak i\u00e7in sinaptik budama hakk\u0131nda konu\u015fmam\u0131z gerekir. Nature Neuroscience'da yay\u0131nlanan bir makaleye g\u00f6re <sup>1<\/sup>, &#8220;<em>sinaptik budama, erken \u00e7ocukluk d\u00f6neminden erken yeti\u015fkinlik d\u00f6nemine kadar ger\u00e7ekle\u015fen sinaps eliminasyonu s\u00fcrecidir.\"<\/em>&nbsp;Beyin geli\u015ftik\u00e7e, \u00e7evresel girdiler n\u00f6ral devreyi \u015fekillendirir. Bu s\u00fcre\u00e7, erken geli\u015fim s\u0131ras\u0131nda olu\u015fan fazla sinapslar\u0131 ortadan kald\u0131r\u0131r ve kalan sinapslar\u0131 g\u00fc\u00e7lendirir.<\/p>\n\n\n\n<p>Ayr\u0131ca, 'sinaptik budama' hipotezine g\u00f6re a\u015f\u0131r\u0131 veya d\u00fczensiz sinaptik budama \u015fizofreni bozuklu\u011fu ile ili\u015fkilidir. Psikiyatrist Irwin Feinberg bu hipotezi 1982 y\u0131l\u0131nda ortaya atm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p>Ayr\u0131ca, birka\u00e7 y\u0131l \u00f6nce, insan beyni g\u00f6r\u00fcnt\u00fcleme ve postmortem \u00e7al\u0131\u015fmalar 'sinaptik budama' hipotezini destekleyen yeni kan\u0131tlar getirmi\u015ftir. Kan\u0131tlar, \u015fizofreni hastalar\u0131n\u0131n kortekslerinde omurga yo\u011funlu\u011funun ve gri maddenin azald\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir.<a href=\"https:\/\/mindthegraph.com\/templates\" target=\"_blank\" rel=\"noopener\"><br><\/a><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69596-1-1024x768.png\" alt=\"preview_69596 (1)\" class=\"wp-image-8555\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<h3>&nbsp;<\/h3>\n\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-1 wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/mindthegraph.com\/science_figures\">Mind the Graph'de \u00e7al\u0131\u015fmaya ba\u015flamaya haz\u0131r m\u0131s\u0131n\u0131z?<\/a><\/div>\n<\/div>\n\n\n\n<h3><strong>&nbsp;Yeni kan\u0131tlar Nature Neuroscience dergisinde yay\u0131mland\u0131:<\/strong><\/h3>\n\n\n\n<p>Bu nedenle bilim insanlar\u0131 \u015fimdi bu fenomenin alt\u0131nda yatan mekanizmay\u0131 anlamaya \u00e7al\u0131\u015f\u0131yor. Carl Sellgren, Roy Perlis ve i\u015fbirlik\u00e7ilerine g\u00f6re ba\u011f\u0131\u015f\u0131kl\u0131k sistemi a\u015f\u0131r\u0131 sinaptik budamada rol oynayabilir. Yeni makaleleri<sup>1<\/sup> Nature neuroscience dergisinde yay\u0131mlanan makalede, \u015fizofreni hastas\u0131na \u00f6zg\u00fc mikroglia arac\u0131l\u0131 sinaps yutulmas\u0131n\u0131 incelemek i\u00e7in h\u00fccresel yeniden programlamay\u0131 uygulayan bir in vitro model tan\u0131mlan\u0131yor.<\/p>\n\n\n\n<p>Mikroglia, beyin ve omurilikte bulunan kolektif bir n\u00f6roglia (glial h\u00fccre) t\u00fcr\u00fcd\u00fcr. Beyinde bulunan t\u00fcm h\u00fccrelerin 10-15%'sini olu\u015ftururlar. Yerle\u015fik makrofaj h\u00fccreleri olarak, merkezi sinir sisteminde (MSS) aktif ba\u011f\u0131\u015f\u0131kl\u0131k savunmas\u0131n\u0131n ilk ve ana bi\u00e7imi olarak hareket ederler. Ayr\u0131ca, mikroglia h\u00fccreleri yabanc\u0131 cisimleri tan\u0131yabilir, yutabilir ve T-h\u00fccrelerini aktive eden antijen sunan h\u00fccreler olarak hareket edebilir.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69544-1024x768.png\" alt=\"preview_69544\" class=\"wp-image-8529\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"1024\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69618-1-1024x1024.png\" alt=\"preview_69618\" class=\"wp-image-8531\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-1024x1024.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-150x150.png 150w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-300x300.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-768x768.png 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1.png 1980w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"640\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69620-1024x640.png\" alt=\"preview_69620\" class=\"wp-image-8532\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-1024x640.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-300x188.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-768x480.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-2 wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/mindthegraph.com\/science_figures\">Mind the Graph'de Yaratmaya \u015eimdi Ba\u015flay\u0131n<\/a><\/div>\n<\/div>\n\n\n\n<h2>Sinirbilim konular\u0131n\u0131 okumaya devam edin<\/h2>\n\n\n\n<ul><li><a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-disease\/#.XJlCeZhKiUk\" target=\"_blank\" rel=\"noopener\">Alzheimer hastal\u0131\u011f\u0131: Bilimsel bir infografik<\/a><\/li><li><a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-graphical-abstracts\/#.XJlCiJhKiUk\" target=\"_blank\" rel=\"noopener\">Alzheimer'\u0131n grafik \u00f6zetleri: Sinirbilimdeki yenilikler g\u00f6rsel bir \u015fekilde<\/a><\/li><\/ul>\n\n\n\n<p>Ara\u015ft\u0131rman\u0131z\u0131 g\u00f6rsel bir \u015fekilde de sunmak istiyorsan\u0131z, grafik \u00f6zetler ve g\u00fczel bilimsel ill\u00fcstrasyonlar g\u00fc\u00e7l\u00fc bir ara\u00e7t\u0131r! Verilerinizi daha g\u00f6rsel hale getirmek i\u00e7in bug\u00fcnden ba\u015flay\u0131n.<\/p>\n\n\n\n<ol><li><a href=\"https:\/\/www.nature.com\/articles\/s41593-018-0334-7\" target=\"_blank\" rel=\"noreferrer noopener\">\u015eizofreni hastalar\u0131ndan t\u00fcretilen sinaptik budama modellerinde mikroglia taraf\u0131ndan artan sinaps eliminasyonu.<\/a><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>\u015eizofreni, bir ki\u015finin nas\u0131l d\u00fc\u015f\u00fcnd\u00fc\u011f\u00fcn\u00fc, hissetti\u011fini ve davrand\u0131\u011f\u0131n\u0131 etkileyen kronik ve ciddi bir zihinsel bozukluktur. \u015eizofreni hastalar\u0131 ger\u00e7eklikle ba\u011flar\u0131n\u0131 kaybetmi\u015f gibi g\u00f6r\u00fcnebilirler. \u015eizofreni geli\u015fimini anlamak i\u00e7in sinaptik budama hakk\u0131nda konu\u015fmam\u0131z gerekir. Nature neuroscience 1'deki bir makaleye g\u00f6re, \"sinaptik budama, sinaps [...]<\/p>","protected":false},"author":11,"featured_media":8536,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[96,554,775],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Neuroscience of nature: see the link between schizophrenia and microglia<\/title>\n<meta name=\"description\" content=\"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/luonto-neurotiede\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neuroscience of nature: see the link between schizophrenia and microglia\" \/>\n<meta property=\"og:description\" content=\"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/tr\/luonto-neurotiede\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-20T21:17:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-19T13:38:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/dfgg.png\" \/>\n\t<meta property=\"og:image:width\" content=\"850\" \/>\n\t<meta property=\"og:image:height\" content=\"519\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Neuroscience of nature: see the link between schizophrenia and microglia","description":"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/tr\/luonto-neurotiede\/","og_locale":"tr_TR","og_type":"article","og_title":"Neuroscience of nature: see the link between schizophrenia and microglia","og_description":"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development","og_url":"https:\/\/mindthegraph.com\/blog\/tr\/luonto-neurotiede\/","og_site_name":"Mind the Graph Blog","article_published_time":"2019-03-20T21:17:14+00:00","article_modified_time":"2022-10-19T13:38:06+00:00","og_image":[{"width":850,"height":519,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/dfgg.png","type":"image\/png"}],"author":"Fabiola Soares","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabiola Soares","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/","url":"https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/","name":"Neuroscience of nature: see the link between schizophrenia and microglia","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2019-03-20T21:17:14+00:00","dateModified":"2022-10-19T13:38:06+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132"},"description":"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/#breadcrumb"},"inLanguage":"tr-TR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Nature neuroscience: the link between schizophrenia and microglia"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr-TR"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132","name":"Fabiola Soares","image":{"@type":"ImageObject","inLanguage":"tr-TR","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","caption":"Fabiola Soares"},"url":"https:\/\/mindthegraph.com\/blog\/tr\/author\/fabiola\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/8527"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/comments?post=8527"}],"version-history":[{"count":14,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/8527\/revisions"}],"predecessor-version":[{"id":23512,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/8527\/revisions\/23512"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/media\/8536"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/media?parent=8527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/categories?post=8527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/tags?post=8527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}