{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/alzheimers-hastaligi\/","title":{"rendered":"Alzheimer hastal\u0131\u011f\u0131: Bilimsel bir infografik"},"content":{"rendered":"

Kullan\u0131c\u0131lar\u0131m\u0131z\u0131n muhte\u015fem \u00e7al\u0131\u015fmalar\u0131n\u0131 g\u00f6rd\u00fc\u011f\u00fcm\u00fczde her zaman bir kutlama ya\u015f\u0131yoruz.\u00a0Zaten yazm\u0131\u015ft\u0131m<\/a> Dr. Alessandra Martini'nin ara\u015ft\u0131rmas\u0131 hakk\u0131nda, Dr.\u00a0Stefania Forner<\/a>\u00a0ve onlar\u0131n meslekta\u015flar\u0131. Onlar Kaliforniya \u00dcniversitesi'nde Doktora Sonras\u0131 Ara\u015ft\u0131rmac\u0131lar ve grafik kullan\u0131c\u0131lar\u0131na dikkat ediyorlar. Birka\u00e7 ay \u00f6nce, onlara infografikler<\/a>\u00a0Dr. Stefania Forner Trends in Neurosciences dergisinde yay\u0131nlanan Alzheimer Hastal\u0131\u011f\u0131nda Sinaptik Bozukluk ba\u015fl\u0131kl\u0131 derleme makale i\u00e7in haz\u0131rlad\u0131: D\u00fczensiz bir senfoni.<\/p>\n

Bug\u00fcn, yeni inceleme makaleleri hakk\u0131nda konu\u015fmak istiyorum Ge\u00e7mi\u015ften gelece\u011fe: hayvan modellerinin Alzheimer Hastal\u0131\u011f\u0131 hakk\u0131nda bize \u00f6\u011frettikleri.<\/a><\/p>\n

Alzheimer hastal\u0131\u011f\u0131 (AH), bili\u015fsel eksikliklere ve haf\u0131za kayb\u0131na neden olan n\u00f6rodejeneratif bir hastal\u0131kt\u0131r. Hastal\u0131\u011f\u0131n mekanizmas\u0131n\u0131 anlamak, hastalar\u0131n ya\u015fam kalitesini art\u0131rmak ve etkili bir tedavi bulmak i\u00e7in \u00f6nemlidir. G\u00fcn\u00fcm\u00fczde, akademi ve ila\u00e7 end\u00fcstrisindeki yo\u011fun \u00e7abalara ra\u011fmen etkili bir tedavi mevcut de\u011fildir. AH, ABD'de \u00f6nde gelen alt\u0131nc\u0131 \u00f6l\u00fcm nedenidir ve d\u00fcnya \u00e7ap\u0131nda 35 milyon ki\u015fiyi etkilemektedir.<\/p>\n

Alzheimer Hastal\u0131\u011f\u0131 infografikleri<\/h2>\n

 <\/p>\n

AD hastalar\u0131n\u0131n \u00e7o\u011funlu\u011fu, genellikle \u00e7e\u015fitli ek hastal\u0131klardan muzdarip olan ya\u015fl\u0131 bireylerdir. Diyabet, osteoporoz, b\u00f6brek hastal\u0131\u011f\u0131, obezite, hipertansiyon ve hiperkol-terolemi\/dislipidemi, inme ve n\u00f6bet, AH'nin ba\u015flang\u0131c\u0131n\u0131 ve ilerlemesini etkileyen ve hastal\u0131\u011f\u0131n patogenezine karma\u015f\u0131kl\u0131k katan ba\u015fl\u0131ca komorbiditelerdir.<\/p>\n

\"infografik
Alzheimer hastal\u0131\u011f\u0131ndaki (AH) komorbiditeleri g\u00f6steren infografik. Ge\u00e7mi\u015ften Gelece\u011fe: Hayvan Modelleri Alzheimer Hastal\u0131\u011f\u0131 Hakk\u0131nda Bize Ne \u00d6\u011fretti?<\/figcaption><\/figure>\n

 <\/p>\n

\n

Son birka\u00e7 on y\u0131ldaki yo\u011fun ara\u015ft\u0131rma \u00e7abalar\u0131na ra\u011fmen, hastal\u0131\u011f\u0131n en yayg\u0131n formunu temsil eden sporadik AD (sAD) etiyolojisinin alt\u0131nda yatan mekanizmalar hala bilinmemektedir. Bunun nedeni, en az\u0131ndan k\u0131smen, sAD hastalar\u0131n\u0131n \u00e7o\u011funun genellikle \u00e7e\u015fitli komorbiditelerden (\u00f6rn. inme, stres, diyabet, n\u00f6betler, osteoporoz ve b\u00f6brek hastal\u0131\u011f\u0131) muzdarip ya\u015fl\u0131 bireyler olmas\u0131d\u0131r.<\/em><\/p>\n<\/blockquote>\n

Bir sonraki infografik, tau ve beta-amiloid oligomerlerinin sinaptik toksisitesinin olu\u015fumunu ve mekanizmalar\u0131n\u0131 g\u00f6stermektedir.<\/p>\n

 <\/p>\n

\"infografico
Ge\u00e7mi\u015ften Gelece\u011fe: Hayvan Modellerinin Alzheimer Hastal\u0131\u011f\u0131 Hakk\u0131nda Bize \u00d6\u011frettikleri<\/figcaption><\/figure>\n

 <\/p>\n

\n

Tauopatiler s\u0131ras\u0131nda dendritik dikenlerin say\u0131s\u0131nda azalma olur. Tau n\u00f6ronun \u00e7ekirde\u011fine girmez ve DNA hasar\u0131na neden olur. Mitokondri say\u0131s\u0131nda ve ayr\u0131ca presinaptik vezik\u00fcl say\u0131s\u0131nda azalma olur ve bu da sinaptik kayba yol a\u00e7ar. Bu kay\u0131p ayn\u0131 zamanda tau'nun dendritlere ve postsinaptik alanlara girmesinden kaynaklanmaktad\u0131r. Tau ayr\u0131ca h\u00fccre d\u0131\u015f\u0131nda toplanarak di\u011fer n\u00f6ronlar taraf\u0131ndan yakalanmas\u0131n\u0131 sa\u011flar.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Ayr\u0131ca Alzheimer hastal\u0131\u011f\u0131 (AD) ile ba\u011flant\u0131l\u0131 enflamatuar mekanizmalar\u0131 g\u00f6stermek i\u00e7in bir infografik olu\u015fturdu<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

Son birka\u00e7 y\u0131ld\u0131r, enflamasyonun beta-amiloid ve tau patolojisini nas\u0131l etkiledi\u011fini anlamakla \u00f6zellikle ilgileniyoruz. Ya\u015fl\u0131 bireyler viral ve bakteriyel enfeksiyonlara kar\u015f\u0131 hassast\u0131r ve bu mikrobiyal ajanlar beyindeki mevcut enflamatuar durumu daha da k\u00f6t\u00fcle\u015ftirerek bili\u015fsel gerilemeyi h\u0131zland\u0131rabilir.<\/em><\/p>\n<\/blockquote>\n

Harika \u00e7al\u0131\u015fmalar\u0131n\u0131z i\u00e7in tebrikler Dr. Stefania Forner!<\/p>\n

E\u011fer bir bilim insan\u0131ysan\u0131z ve makaleniz i\u00e7in g\u00fczel \u015fekiller olu\u015fturmak istiyorsan\u0131z, hemen \u015fimdi bir mind the graph kullan\u0131c\u0131s\u0131 olabilirsiniz.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Kullan\u0131c\u0131lar\u0131m\u0131z\u0131n harika \u00e7al\u0131\u015fmalar\u0131n\u0131 g\u00f6rd\u00fc\u011f\u00fcm\u00fczde her zaman bir kutlama ya\u015f\u0131yoruz. Dr. Alessandra Martini, Dr. Stefania Forner ve meslekta\u015flar\u0131n\u0131n ara\u015ft\u0131rmalar\u0131 hakk\u0131nda daha \u00f6nce yazm\u0131\u015ft\u0131m. Onlar Kaliforniya \u00dcniversitesi'nde Doktora Sonras\u0131 Ara\u015ft\u0131rmac\u0131lar ve grafik kullan\u0131c\u0131lar\u0131n\u0131 d\u00fc\u015f\u00fcn\u00fcyorlar. Birka\u00e7 ay \u00f6nce, Dr. Stefania Forner'in Trends [...] dergisinde yay\u0131nlanan inceleme makalesi i\u00e7in olu\u015fturdu\u011fu infografikleri g\u00f6stermi\u015ftim.<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/tr\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-23T18:56:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:30:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png\" \/>\n\t<meta property=\"og:image:width\" content=\"755\" \/>\n\t<meta property=\"og:image:height\" content=\"487\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/tr\/alzheimers-sykdom\/","og_locale":"tr_TR","og_type":"article","og_title":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","og_description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","og_url":"https:\/\/mindthegraph.com\/blog\/tr\/alzheimers-sykdom\/","og_site_name":"Mind the Graph Blog","article_published_time":"2018-08-23T18:56:09+00:00","article_modified_time":"2022-10-18T11:30:53+00:00","og_image":[{"width":755,"height":487,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png","type":"image\/png"}],"author":"Fabiola Soares","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabiola Soares","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/","url":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/","name":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2018-08-23T18:56:09+00:00","dateModified":"2022-10-18T11:30:53+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132"},"description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/#breadcrumb"},"inLanguage":"tr-TR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Alzheimer\u2019s disease: A scientific infographic"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr-TR"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132","name":"Fabiola Soares","image":{"@type":"ImageObject","inLanguage":"tr-TR","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","caption":"Fabiola Soares"},"url":"https:\/\/mindthegraph.com\/blog\/tr\/author\/fabiola\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/8064"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/comments?post=8064"}],"version-history":[{"count":14,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/8064\/revisions"}],"predecessor-version":[{"id":23414,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/8064\/revisions\/23414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/media\/8067"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/media?parent=8064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/categories?post=8064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/tags?post=8064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}