{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/otofaji-kazandi-nobel-odulu-tip\/","title":{"rendered":"Otofaji Nobel T\u0131p \u00d6d\u00fcl\u00fc'n\u00fc kazand\u0131"},"content":{"rendered":"

Otofaji s\u00fcreci, kanser ve n\u00f6rolojik hastal\u0131klar gibi \u00e7e\u015fitli durumlarla ilgilidir. V\u00fccudun dahili geri d\u00f6n\u00fc\u015f\u00fcm program\u0131 olarak \u00e7al\u0131\u015f\u0131r. Bununla birlikte, i\u015flevsiz otofaji Parkinson hastal\u0131\u011f\u0131, diyabet, kanser ve di\u011fer ya\u015fa ba\u011fl\u0131 bozukluklarla ili\u015fkilendirilmi\u015ftir.<\/p>\n

Otofaji s\u00fcrecinin \u00f6nemine ili\u015fkin bu k\u00fc\u00e7\u00fck giri\u015ften sonra, bu alandaki yeni ke\u015fiflerin bir Nobel \u00d6d\u00fcl\u00fc'ne yol a\u00e7mas\u0131 \u015fa\u015f\u0131rt\u0131c\u0131 de\u011fildir. Nitekim ge\u00e7ti\u011fimiz Pazartesi g\u00fcn\u00fc ara\u015ft\u0131rmac\u0131 Yoshino Ohsumi Nobel T\u0131p \u00d6d\u00fcl\u00fc<\/a> otofaji i\u00e7in gerekli ilk genleri tan\u0131mlamak i\u00e7in.<\/p>\n

\"\u00c7ok fazla insanla rekabet etmekten ho\u015flanm\u0131yorum ve bunun yerine kimsenin yapmad\u0131\u011f\u0131 bir \u015feyi yapmay\u0131 daha keyifli buluyorum. Bir bak\u0131ma bilim de bununla ilgili ve bir \u015fey bulman\u0131n keyfi bana ilham veriyor.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Ohsumi bunu nas\u0131l yapt\u0131?<\/h3>\n

Ohsumi laboratuvar\u0131nda, a\u00e7l\u0131k s\u0131ras\u0131nda otofagozom biriktiren maya su\u015flar\u0131 tasarlam\u0131\u015ft\u0131. Bu birikim ancak otofaji i\u00e7in gerekli genlerin inaktif olmas\u0131 durumunda ger\u00e7ekle\u015febilirdi. B\u00f6ylece Ohsumi, h\u00fccreleri \u00e7e\u015fitli gen mutasyonlar\u0131yla manip\u00fcle etmeye ba\u015flad\u0131 ve otofajiyi ind\u00fcklemeyi ba\u015fard\u0131.<\/p>\n

\"Otofaji<\/a><\/p>\n

Otofaji uzun zamand\u0131r<\/h3>\n

Otofaji son 50 y\u0131ld\u0131r bilinmesine ra\u011fmen, bu s\u00fcrecin \u00f6neminin anla\u015f\u0131lmas\u0131 ancak 1990'larda Ohsumi'nin \u00e7al\u0131\u015fmalar\u0131yla olmu\u015ftur.
\nOhsumi \u00e7al\u0131\u015fmalar\u0131yla \u015fimdiden baz\u0131 hayranlar kazand\u0131:<\/p>\n

\"Otofaji<\/a><\/p>\n

\n

\"Bu y\u0131lki Nobel \u00f6d\u00fcl\u00fcn\u00fc ald\u0131\u011f\u0131 i\u00e7in \u00e7ok mutluyum, \u00e7ok iyi hak etti. Laboratuvar\u0131 a\u011f\u0131rl\u0131kl\u0131 olarak maya \u00fczerinde \u00e7al\u0131\u015f\u0131yor. Otofajide rol oynayan kilit genlerin ke\u015ffedilmesini sa\u011flayan ilk taramalar\u0131 yapt\u0131lar. Pek \u00e7ok ba\u015fka laboratuar, hastal\u0131klarda neden \u00f6nemli oldu\u011funu g\u00f6rmek i\u00e7in do\u011frudan ya da dolayl\u0131 olarak onun ke\u015fiflerinden yararland\u0131.\"<\/p>\n

David Rubinsztein<\/a> - Cambridge T\u0131bbi Ara\u015ft\u0131rma Enstit\u00fcs\u00fc m\u00fcd\u00fcr yard\u0131mc\u0131s\u0131<\/p>\n<\/blockquote>\n

\"Otofaji<\/a><\/p>\n

\n

\"Bilimin bu alan\u0131n\u0131n tan\u0131nmas\u0131n\u0131n \u00e7ok \u00f6nemli oldu\u011funu d\u00fc\u015f\u00fcn\u00fcyorum. Buradaki \u00f6nemli ilke, hastal\u0131ktaki ortak mekanizmalar\u0131 ara\u015ft\u0131rmakt\u0131r. Bu, bu bozukluklar\u0131 tedavi etmek i\u00e7in daha geleneksel hastal\u0131\u011fa \u00f6zg\u00fc yakla\u015f\u0131mlardan farkl\u0131 yollar a\u00e7\u0131yor.\"<\/p>\n

Giovanna Mallucci<\/a> - Cambridge \u00dcniversitesi'nde klinik n\u00f6robilim profes\u00f6r\u00fc<\/p>\n<\/blockquote>\n

\"Otofaji<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Otofaji s\u00fcreci, kanser ve n\u00f6rolojik hastal\u0131klar gibi \u00e7e\u015fitli durumlarla ilgilidir. V\u00fccudun dahili geri d\u00f6n\u00fc\u015f\u00fcm program\u0131 olarak \u00e7al\u0131\u015f\u0131r. Bununla birlikte, i\u015flevsiz otofaji Parkinson hastal\u0131\u011f\u0131, diyabet, kanser ve di\u011fer ya\u015fa ba\u011fl\u0131 bozukluklarla ili\u015fkilendirilmi\u015ftir. Otofaji s\u00fcrecinin \u00f6nemine ili\u015fkin bu k\u00fc\u00e7\u00fck giri\u015ften sonra, yeni ke\u015fiflerin [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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