{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/zika-virus-graphical-abstract\/","title":{"rendered":"Mikrosefali \u00fczerine Zika vir\u00fcs\u00fc grafik \u00f6zeti"},"content":{"rendered":"

Zika vir\u00fcs\u00fcn\u00fcn grafiksel \u00f6zetini anlay\u0131n: Beyin boyutunu nas\u0131l k\u00fc\u00e7\u00fclt\u00fcyor?<\/h3>\n

Bug\u00fcn yap\u0131lan bir ara\u015ft\u0131rma, Zika vir\u00fcs\u00fcn\u00fcn sinir dokular\u0131ndaki malformasyondaki rol\u00fcne ili\u015fkin ilgin\u00e7 kan\u0131tlar ortaya koydu. Evet, siz sormadan s\u00f6yleyeyim, insan sinir dokusu.<\/p>\n

Bu, k\u00f6k h\u00fccre ara\u015ft\u0131rmalar\u0131 ve son zamanlarda h\u00fccre yeniden programlama alan\u0131nda uluslararas\u0131 \u00fcne sahip bir ara\u015ft\u0131rmac\u0131 olan Dr. Stevens Rehen'in grubu taraf\u0131ndan zarif bir \u015fekilde yap\u0131ld\u0131.<\/p>\n

A\u015fa\u011f\u0131daki \u015fekil a\u015fa\u011f\u0131daki bulgular\u0131 \u00f6zetlemektedir Ka\u011f\u0131t<\/a>ama k\u0131saca a\u00e7\u0131klamaya \u00e7al\u0131\u015faca\u011f\u0131m.<\/p>\n

 <\/p>\n

\"blog<\/p>\n

Bu anlay\u0131\u015fl\u0131 Zika vir\u00fcs\u00fc grafik \u00f6zeti Mind the graph ile yap\u0131ld\u0131. Harika de\u011fil mi?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Yukar\u0131daki resimde de g\u00f6rebilece\u011finiz gibi, bu ara\u015ft\u0131rmada \u00fc\u00e7 farkl\u0131 yakla\u015f\u0131m benimsenmi\u015ftir. Hepsi de Zika vir\u00fcs\u00fcn\u00fcn beyin h\u00fccrelerinin uygun bir n\u00f6ronal doku olu\u015fturmak \u00fczere nas\u0131l evrimle\u015fti\u011fi \u00fczerinde do\u011frudan bir etkisi oldu\u011funu, di\u011fer bir deyi\u015fle \"beyin malformasyonunu i\u00e7erdi\u011fini\" do\u011fruluyor.\"zika<\/a>Mikrosefali sadece bir beyin malformasyonudur. Makalenin \u00f6ne s\u00fcrd\u00fc\u011f\u00fc \u015fey daha da temel bir \u015fey.<\/p>\n

Zika vir\u00fcs\u00fcn\u00fcn nas\u0131l yay\u0131ld\u0131\u011f\u0131n\u0131 g\u00f6steriyorlar:<\/p>\n

    \n
  1. H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc te\u015fvik eder<\/li>\n
  2. Morfolojik de\u011fi\u015fikliklere neden olur (n\u00f6rosferlerde)<\/li>\n
  3. Serebral organoidlerin (mini beyinler) b\u00fcy\u00fcmesini\/b\u00fcy\u00fckl\u00fc\u011f\u00fcn\u00fc azalt\u0131r<\/li>\n<\/ol>\n

    T\u00fcm bunlar, Zika vir\u00fcs\u00fcn\u00fcn insan beyninin geli\u015fimi s\u0131ras\u0131nda n\u00f6rogenezi nas\u0131l etkiledi\u011finin ve a\u015fa\u011f\u0131da g\u00f6rd\u00fc\u011f\u00fcn\u00fcz fenotipe nas\u0131l neden oldu\u011funun yollar\u0131d\u0131r.<\/p>\n

    \"zika<\/a><\/p>\n

    <\/h3>\n

    Neden daha \u00f6nce yap\u0131lmad\u0131?<\/h3>\n

    \u00c7\u0131\u011f\u0131r a\u00e7an yakla\u015f\u0131m, insan h\u00fccrelerinde vir\u00fcs enfeksiyonunu inceleyebilmek i\u00e7in ind\u00fcklenmi\u015f pluripotens k\u00f6k h\u00fccrelerinin (iPS h\u00fccreleri) kullan\u0131lmas\u0131yd\u0131.<\/p>\n

    Bu i\u015flemle, bir insandan al\u0131nan somatik bir h\u00fccre, ba\u015flang\u0131\u00e7taki pluripotent h\u00fccre durumuna do\u011fru yeniden programlan\u0131r ve daha sonra farkl\u0131 h\u00fccrelere, dokulara ve daha yak\u0131n zamanda organlara farkl\u0131la\u015ft\u0131r\u0131labilir. Bu, \"insan doku m\u00fchendisli\u011finin\" ba\u015flang\u0131c\u0131d\u0131r.<\/p>\n

    \u00c7al\u0131\u015fmada yazarlar sadece iPS h\u00fccrelerini kullanmakla kalmam\u0131\u015f, ayn\u0131 zamanda beyin organoidleri<\/a>Zika vir\u00fcs\u00fcn\u00fcn varl\u0131\u011f\u0131n\u0131n bu n\u00f6ronal dokunun olu\u015fumunu nas\u0131l etkiledi\u011fini anlamak i\u00e7in \"mini beyinler\" olarak da bilinir.<\/p>\n

    Bunun gibi h\u00fccre k\u00fclt\u00fcrleri \u00fc\u00e7 boyutlu (3D) yap\u0131lar olarak kabul edilir ve organ mimarisi hakk\u0131nda daha fazla ipucu sa\u011flar. Bu organoidin y\u0131l\u0131 Ekonomist<\/a>. Bilim insanlar\u0131 bu yenilik\u00e7i yakla\u015f\u0131m\u0131 kullanarak, zika vir\u00fcs\u00fcn\u00fcn insan beyin h\u00fccrelerini nas\u0131l hedef ald\u0131\u011f\u0131n\u0131 ve bunlar\u0131n n\u00f6rosferler ve serebral organoidler olarak canl\u0131l\u0131klar\u0131n\u0131 ve b\u00fcy\u00fcmelerini nas\u0131l azaltt\u0131\u011f\u0131n\u0131 anlayabildiler.<\/p>\n

    Bu Ka\u011f\u0131t<\/a> yenilik\u00e7i PeerJ dergisinde \u00f6n bask\u0131da. Hatta s\u00fcre\u00e7 boyunca yorum yapabilir ve yazarlar\u0131n \u00e7al\u0131\u015fmay\u0131 geli\u015ftirmesine yard\u0131mc\u0131 olabilirsiniz. A\u015fa\u011f\u0131da \u00f6zeti g\u00f6rebilir ve t\u0131klayarak tam eri\u015fime sahip olabilirsiniz Burada<\/a>.<\/p>\n

    \"zika<\/a><\/p>\n

    Not: PeerJ'deki Mart 2016 tarihli \u00f6n bask\u0131dan iki ay sonra nihai makale yay\u0131nland\u0131 ve s\u00fcrpriz bir \u015fekilde Science'da yay\u0131nland\u0131 <\/a>Magazine, gezegendeki en prestijli bilimsel dergilerden biri.<\/p>\n

    -> Garcez ve arkada\u015flar\u0131n\u0131n Science dergisindeki makalesinin tamam\u0131n\u0131 okuyun <-<\/a><\/p>\n

    \"zika<\/a><\/p>\n

    Bu g\u00f6nderiyi payla\u015farak daha fazla insan\u0131n bundan haberdar olmas\u0131n\u0131 sa\u011flay\u0131n. Bu, daha \u00f6nce de belirtildi\u011fi gibi, k\u00fcresel bir halk sa\u011fl\u0131\u011f\u0131 meselesidir. D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc<\/a>\u00a0(WHO).<\/p>\n

    \n

     <\/p>\n

    Ne oldu\u011funu bilin DS\u00d6'den Zika vir\u00fcs\u00fc hakk\u0131nda tavsiyeler<\/a>\u00a0bula\u015fma ve enfeksiyon:<\/p>\n

    \n

    \u015eanz\u0131man<\/h3>\n

    Zika vir\u00fcs\u00fc insanlara \u00f6ncelikle \u015fu hayvanlardan \u0131s\u0131r\u0131k yoluyla bula\u015f\u0131r Aedes<\/i> Kentsel alanlarda genellikle binalar\u0131n etraf\u0131nda ya\u015fayan ve genellikle g\u00fcnd\u00fcz saatlerinde aktif olan sivrisinekler (en yo\u011fun \u0131s\u0131rma aktivitesi sabah\u0131n erken saatlerinde ve \u00f6\u011fleden sonralar\u0131 ger\u00e7ekle\u015fir).<\/p>\n

    Baz\u0131 kan\u0131tlar Zika vir\u00fcs\u00fcn\u00fcn kan nakli, perinatal bula\u015fma ve cinsel bula\u015fma yoluyla da insanlara bula\u015fabilece\u011fini g\u00f6stermektedir. Ancak bu yollara \u00e7ok nadir rastlanmaktad\u0131r.<\/p>\n

    Kulu\u00e7ka s\u00fcresi tipik olarak 2 ila 7 g\u00fcn aras\u0131ndad\u0131r.<\/p>\n

    Belirtiler ve semptomlar<\/h3>\n

    Zika vir\u00fcs\u00fc enfeksiyonu, s\u0131kl\u0131kla mak\u00fclopap\u00fcler d\u00f6k\u00fcnt\u00fcn\u00fcn e\u015flik etti\u011fi d\u00fc\u015f\u00fck dereceli ate\u015f (38,5\u00b0C'nin alt\u0131nda) ile karakterizedir. Di\u011fer yayg\u0131n semptomlar aras\u0131nda kas a\u011fr\u0131s\u0131, olas\u0131 \u015fi\u015flikle birlikte eklem a\u011fr\u0131s\u0131 (\u00f6zellikle el ve ayaklar\u0131n k\u00fc\u00e7\u00fck eklemlerinde), ba\u015f a\u011fr\u0131s\u0131, g\u00f6zlerin arkas\u0131nda a\u011fr\u0131 ve konjonktivit yer al\u0131r. Belirtiler genellikle hafif oldu\u011fu i\u00e7in enfeksiyon fark edilmeyebilir veya dang olarak yanl\u0131\u015f te\u015fhis edilebilir.<\/p>\n

    Dang vir\u00fcs\u00fc ve Bat\u0131 Nil vir\u00fcs\u00fc gibi di\u011fer flavivir\u00fcslere benzer \u015fekilde, Zika vir\u00fcs\u00fc ile y\u00fcksek oranda asemptomatik enfeksiyon beklenmektedir. \u00c7o\u011fu insan ciddi komplikasyonlar olmadan tamamen iyile\u015fir ve hastaneye yat\u0131\u015f oranlar\u0131 d\u00fc\u015f\u00fckt\u00fcr. Bug\u00fcne kadar Zika vir\u00fcs\u00fc ile ili\u015fkili herhangi bir \u00f6l\u00fcm vakas\u0131 bildirilmemi\u015ftir.<\/p><\/blockquote>\n

     <\/p>\n

    3 May\u0131s 2016 tarihinde g\u00fcncellenmi\u015ftir.<\/p>","protected":false},"excerpt":{"rendered":"

    Zika vir\u00fcs\u00fcn\u00fc anlay\u0131n grafik \u00f6zet: Beyin boyutunu nas\u0131l k\u00fc\u00e7\u00fclt\u00fcyor Bug\u00fcn yap\u0131lan bir ara\u015ft\u0131rma, Zika vir\u00fcs\u00fcn\u00fcn sinir dokular\u0131n\u0131n malformasyonundaki rol\u00fcne y\u00f6nelik ilgin\u00e7 kan\u0131tlar ekledi. Ah, evet, siz sormadan \u00f6nce, insan sinir dokusu. Bu \u00e7al\u0131\u015fma, Zika vir\u00fcs\u00fc alan\u0131nda uluslararas\u0131 \u00fcne sahip bir ara\u015ft\u0131rmac\u0131 olan Dr. Stevens Rehen'in grubu taraf\u0131ndan zarif bir \u015fekilde [...]<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. 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