{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/karaciger-fibrozunda-basari-durumu-nukleer-reseptorler\/","title":{"rendered":"Karaci\u011fer fibrozunda n\u00fckleer resept\u00f6rler Makale \u0130ncelemesi"},"content":{"rendered":"<p>Bu durumda yazar, farkl\u0131 kaynaklardan ald\u0131\u011f\u0131 \u015fekilleri tek bir yerde derlemek i\u00e7in Mind the Graph'yi kulland\u0131. En iyi bilimsel do\u011fru \u00e7izimlerin yan\u0131 s\u0131ra, \u00e7al\u0131\u015fma alan\u0131m\u0131z kullan\u0131c\u0131 dostu bir aray\u00fcze sahiptir ve kullan\u0131m\u0131 \u00e7ok kolayd\u0131r.<\/p>\n\n\n\n<p>Tamam\u0131n\u0131 kontrol edin <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S092544392100168X?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">orijinal makale<\/a>. <\/p>\n\n\n\n<h2><strong>Karaci\u011fer fibrozunda n\u00fckleer resept\u00f6rlerin rol\u00fc<\/strong><\/h2>\n\n\n\n<p>Philipp K\u00f6nigshofer ve arkada\u015flar\u0131 (2021), n\u00fckleer resept\u00f6rlerin karaci\u011fer fibrozunda rol oynayan \u00e7e\u015fitli anahtar molek\u00fcler sinyallerin gen ekspresyonunu d\u00fczenleyen ligandla aktive edilen transkripsiyon fakt\u00f6rleri oldu\u011funu bildirmektedir. <\/p>\n\n\n\n<p>Karaci\u011fer fibrogenezinin birincil h\u00fccresel s\u00fcr\u00fcc\u00fcs\u00fc aktive hepatik stellat h\u00fccrelerdir. Farkl\u0131 n\u00fckleer resept\u00f6rler, pro-enflamatuar ve pro-fibrojenik sitokinlerin hepatik ekspresyonunu d\u00fczenler.<\/p>\n\n\n\n<h2><strong>Mind the Graph taraf\u0131ndan desteklenen Grafiksel \u00d6zetler<\/strong> <strong>bu makalede<\/strong><\/h2>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1.jpg\"><img decoding=\"async\" loading=\"lazy\" width=\"800\" height=\"389\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1.jpg\" alt=\"\" class=\"wp-image-20242\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1.jpg 800w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1-300x146.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1-768x373.jpg 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1-18x9.jpg 18w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1-100x49.jpg 100w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>ile yap\u0131lm\u0131\u015ft\u0131r <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Bu ilk \u015fekil, n\u00fckleer resept\u00f6rlere genel bir bak\u0131\u015f ve alt ailelere g\u00f6re s\u0131n\u0131fland\u0131rmad\u0131r.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2.jpg\"><img decoding=\"async\" loading=\"lazy\" width=\"800\" height=\"468\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2.jpg\" alt=\"\" class=\"wp-image-20246\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2.jpg 800w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2-300x176.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2-768x449.jpg 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2-18x12.jpg 18w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2-100x59.jpg 100w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>ile yap\u0131lm\u0131\u015ft\u0131r <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Yukar\u0131da n\u00fckleer resept\u00f6r efekt\u00f6r i\u015flevlerinin farkl\u0131 t\u00fcrlerini g\u00f6rebiliriz.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s2.0-S092544392100168X-gr3.jpg\"><img decoding=\"async\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s2.0-S092544392100168X-gr3.jpg\" alt=\"\" class=\"wp-image-20245\"\/><\/a><figcaption class=\"wp-element-caption\"><em>ile yap\u0131lm\u0131\u015ft\u0131r <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>\u00dc\u00e7\u00fcnc\u00fc \u015fekilde, karaci\u011fer hastal\u0131klar\u0131na kar\u015f\u0131 potansiyel terap\u00f6tik yakla\u015f\u0131mlar olarak NR mod\u00fclasyonlar\u0131n\u0131n bildirilen etkilerine genel bir bak\u0131\u015f\u0131 kontrol edebiliriz. <\/p>\n\n\n\n<p>Oklar, karaci\u011fer hastal\u0131\u011f\u0131nda \u00f6ng\u00f6r\u00fclen faydal\u0131 etkileri g\u00f6stermektedir <span style=\"color:#0d880f\" class=\"has-inline-color\"><strong>yukar\u0131- (koyu ye\u015fil)<\/strong><\/span> veya<strong><span class=\"has-inline-color has-vivid-green-cyan-color\"> a\u015fa\u011f\u0131- (a\u00e7\u0131k ye\u015fil)<\/span><\/strong> Karaci\u011fer fibrozunun gerilemesini destekledi\u011fi veya karaci\u011fer fibrozunu azaltt\u0131\u011f\u0131 bildirilen spesifik mekanizmalar\u0131n d\u00fczenlenmesi. <\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-luminous-vivid-orange-color\">Turuncu oklar<\/mark><\/strong> NR mod\u00fclasyonunun tart\u0131\u015fmal\u0131 ya da hen\u00fcz yeterince de\u011ferlendirilmemi\u015f etkilerini ve mekanizmalar\u0131n\u0131 g\u00f6stermektedir.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5.jpg\"><img decoding=\"async\" loading=\"lazy\" width=\"800\" height=\"431\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5.jpg\" alt=\"\" class=\"wp-image-20244\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5.jpg 800w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5-300x162.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5-768x414.jpg 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5-18x10.jpg 18w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5-100x54.jpg 100w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>ile yap\u0131lm\u0131\u015ft\u0131r <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Son \u015fekil, karaci\u011fer fibrozisi i\u00e7in potansiyel bir tedavi olarak NR mod\u00fclat\u00f6rlerinin a\u011f\u0131rl\u0131kl\u0131 olarak HSC'lerde meydana geldi\u011fi bildirilen molek\u00fcler etkilerini temsil etmektedir.<\/p>\n\n\n\n<p>K\u00f6nigshofer ve meslekta\u015flar\u0131, n\u00fckleer resept\u00f6rlerle ili\u015fkili sinyalizasyon \u00fczerine daha fazla ara\u015ft\u0131rma yap\u0131lmas\u0131n\u0131n, karaci\u011fer hastal\u0131\u011f\u0131 olan hastalar i\u00e7in etkili anti-fibrotik tedavilerin klinik olarak geli\u015ftirilmesine yol a\u00e7abilece\u011fini \u00f6ne s\u00fcrmektedir.<\/p>\n\n\n\n<h2><strong>Belgeler Etki ve Performans<\/strong><\/h2>\n\n\n\n<p>Ayn\u0131 takvim y\u0131l\u0131nda s\u00f6z konusu dergide yay\u0131nlanan di\u011fer makaleler\/incelemeler ile metriklerin 1 y\u0131ll\u0131k bir se\u00e7enek kar\u015f\u0131la\u015ft\u0131rmas\u0131n\u0131 se\u00e7erek \u015funlar\u0131 fark edebiliriz <strong>bu makaleye 57%'sinden daha fazla at\u0131f yap\u0131ld\u0131<\/strong>.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/Nuclear-receptors.png\"><img decoding=\"async\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/Nuclear-receptors.png\" alt=\"\" class=\"wp-image-20247\"\/><\/a><figcaption class=\"wp-element-caption\"><em>Kaynak <a href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1016\/j.bbadis.2021.166235&amp;theme=plum-sciencedirect-theme&amp;hideUsage=true\" target=\"_blank\" rel=\"noreferrer noopener\">PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Makalenizi g\u00fc\u00e7lendirmek i\u00e7in infografiklerin g\u00fcc\u00fcn\u00fc de kullan\u0131n. Mind the Graph'yi deneyin!<\/p>\n\n\n\n<div class=\"is-layout-flex wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/mindthegraph.com\/app\/auth\/register?from_url=\/\" style=\"border-radius:100px;background-color:#dc1866\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Mind the Graph'yi deneyin<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Bu makalede, karaci\u011fer fibrozundaki n\u00fckleer resept\u00f6rleri temsil etmek i\u00e7in Mind the Graph ile yap\u0131lm\u0131\u015f bilimsel \u00e7izimler bulunmaktad\u0131r.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/karaciger-fibrozunda-basari-durumu-nukleer-reseptorler\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/tr\/karaciger-fibrozunda-basari-durumu-nukleer-reseptorler\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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